Silicon microdosimeters for the characterisation of mixed radiation fields relevant to the space radiation environment have been under continual development at the Centre for Medical Radiation Physics for over a decade. These devices are useful for the prediction of single event upsets in microelectronics and for radiation protection of spacecraft crew. The latest development in silicon microdo...

Studying the response of neuronal networks to radio frequency (RF) signals requires use a specific device capable accessing and simultaneously recording activity during electromagnetic fields (EMF) exposure. In this study, microelectrode array (MEA) that records spontaneous neurons is coupled an open transverse (TEM) cell propagates EMF. We characterize system both numerically experimentally at...

It is an established fact that radon progeny can induce lung cancers. However, there is a well-known discrepancy between the epidemiologically derived dose conversion factor for radon progeny (4 mSv/WLM) and the dosimetrically derived value (15 mSv/WLM) (mSv is a unit of the dose while WLM is a unit of exposure to radon progeny). Up to now there is no satisfactory explanation to this. In the pr...

Preclinical experiments are carried out with approximately 20-30 microm wide, approximately 10 mm high parallel microbeams of hard, broad-"white"-spectrum x rays (approximately 50-600 keV) to investigate microbeam radiation therapy (MRT) of brain tumors in infants for whom other kinds of radiotherapy are inadequate and/or unsafe. Novel physical microdosimetry (implemented with MOSFET chips in t...

Introduction: NanOx is a theoretical framework developed to predict cell survival ionizing radiation in the context of radiotherapy. Based on statistical physics, takes stochastic nature at different spatial scales fully into account. It extends concepts from microdosimetry nanodosimetry, and considers as well primary oxidative stress. This article presents detail general formalism behind NanOx...

The phase 1 clinical trial of systemic Targeted Alpha Therapy for metastatic melanoma has shown that solid tumours can be regressed by alpha radiation. However, patient blood vessels and lymphocytes inevitably received a background radiation from non-targeted alpha decays in the blood circulation. To determine the toxicity of alpha particle to normal tissue capillaries and peripheral blood lymp...

Researchers in bioelectromagnetics often require realistic tissue, cellular and sub-cellular geometry models for their simulations. However, biological shapes are often extremely irregular, while conventional geometrical modeling tools on the market cannot meet the demand for fast and efficient construction of irregular geometries. We have designed a free, user-friendly tool in MATLAB that comb...

Introduction: The goal of any type of radiation therapy in the treatment of tumors, in addition to destroying cancer cells, is to minimizing radiation to nearby healthy cells and thus reducing side damages. For this purpose, targeted radiation therapy (TRT) is more effective in treating of single cells or small cluster of cells. The main factor in the success of this method is...