Abstract Aiming to evaluate cortical bone microarchitecture and osteonal morphology after irradiation, twelve male New Zealand rabbits were used. The animals divided: control group (no radiation-NIr); 3 irradiated groups, sacrificed after: 7 (Ir7d); 14 (Ir14d) 21 (Ir21d) days. A single radiation dose of 30 Gy was Computed microtomography analyzed the microarchitecture: thickness (CtTh), volume ...

STUDY OBJECTIVES (a) Develop a new statistical approach to describe the microarchitecture of wakefulness and sleep in mice; (b) evaluate differences among inbred strains in this microarchitecture; (c) compare results when data are scored in 4-s versus 10-s epochs. DESIGN Studies in male mice of four inbred strains: AJ, C57BL/6, DBA and PWD. EEG/EMG were recorded for 24h and scored independent...

BACKGROUND Measurement of bone mineral density by dual x-ray absorptiometry combined with clinical risk factors is currently the gold standard in diagnosing osteoporosis. Advanced imaging has shown that older patients with fragility fractures have poor bone microarchitecture, often independent of low bone mineral density. We hypothesized that premenopausal women with a fracture of the distal en...

Background: Trabecular Bone Score (TBS) is an index of bone microarchitecture that provides additional skeletal information to areal Mineral Density (aBMD). Recently TBS data has been used optimize the Fracture Risk Assessment Tool (FRAX) predictive value. Aim this study was evaluate clinical value on FRAX algorithm.

In pancreatic cancer (PDAC) intratumor infiltration of polymorphonuclear neutrophils (PMN) is associated with histologically apparent alterations of the tumor growth pattern. The aim of this study was to examine possible associations between PMN infiltration, tumor microarchitecture, and water diffusivity in diffusion-weighted magnetic resonance imaging (DW-MRI), and to further asses the underl...

Disorganization of the valve extracellular matrix (ECM) is a hallmark of calcific aortic valve disease (CAVD). However, while microarchitectural features of the ECM can strongly influence the biological and mechanical behavior of tissues, little is known about the ECM microarchitecture in CAVD. In this work, we apply advanced imaging techniques to quantify spatially heterogeneous changes in col...