نتایج جستجو برای: michaelis menten equation
تعداد نتایج: 233616 فیلتر نتایج به سال:
Many problems of enzyme kinetics can be described by a function known as the Michaelis-Menten (M-M) function. In this paper, motivated by the importance of Michaelis-Menten function in biochemistry and other biological phenomena, we have introduced a new class of generalized Pearson distribution arising from Michaelis-Menten function. Various properties of this distribution are derived, for exa...
Recent single-molecule enzymology measurements with improved statistics have demonstrated that a single enzyme molecule exhibits large temporal fluctuations of the turnover rate constant at a broad range of time scales (from 1 ms to 100 s). The rate constant fluctuations, termed as dynamic disorder, are associated with fluctuations of the protein conformations observed on the same time scales. ...
• This paper studies the Michaelis–Menten model (MM), which plays an important role in pharmacokinetics, from a theoretical as well as a computational point of view. An analytical method for the nonlinear least squares estimation of the MM is introduced. It is proved that the MM model has not a unique parameter estimation (through the nonlinear least squares), and there is not a unique optimal ...
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