IntroductionClinicians need reliable outcome predictors to improve the prognosis of septic patients. Mouse models are widely used in sepsis research. We aimed review how mouse were search for novel prognostic biomarkers order optimize their use future biomarker discovery.MethodsWe searched PubMed from 2012 July 2022 using “((sepsis) AND (mice)) ((prognosis) OR (prognostic biomarker))”.ResultsA ...

Aims: Peritonitis is one of the most common causes sepsis, a serious syndrome characterized by dysregulated systemic inflammatory response. Recent evidence suggests that Granzyme A (GzmA), serine protease mainly expressed NK and T cells, could act as proinflammatory mediator play an important role in pathogenesis sepsis. This work aims to analyze therapeutic potential GzmA peritoneal Methods: T...

The Eμ-TCL1 model is the most widely used syngeneic mouse of chronic lymphocytic leukemia (CLL) and has been extensively to understand pathogenesis select genes, effect immune microenvironment for pre-clinical drug development studies. Recently there an increasing awareness impact age sex differences on cancers along with efficacy toxicity specific cancer therapies. However, despite predominanc...

Delta-9-tetrahydrocannabinol (THC) is the primary psychoactive compound of cannabis plant and an exogenous ligand endocannabinoid system. In previous studies, we demonstrated that a single microdose THC (0.002 mg/kg, 3–4 orders magnitude lower than standard dose for rodents) exerts distinct, long-term neuroprotection in model mice subjected to acute neurological insults. When administered old, ...

Abstract B cell Maturation Antigen (BCMA) is a receptor that engages the cytokines BAFF and APRIL. BCMA known to play critical role in regulating proliferation, survival, differentiation into plasma cells. However, effect of on non-B cells has been understudied. We have previously shown regulates EAE, where −/−mice exacerbated disease compared +/+mice. The increased was associated with infiltra...

Abstract Alphaviruses are a group of arthropod-borne viruses that have the capacity to cause encephalomyelitis, which is inflammation brain and spinal cord due immune response viral infection, can result in fever, headache, neurologic disease such as cognitive impairment, seizures, ataxia, paralysis. Neurons primary target cells Sindbis virus (SINV), prototypic alphavirus; however, indispensabl...

background: gts, ptsm and atsm are bis-thiosemicarbazone ligands used in the preparation of copper radiopharmaceuticals. chemical structure of these materials indicates that they should have radio-protective effects. objective: to study the radio-protective effects of gts, ptsm and atsm. methods: this study has focused on radio-protective effects of these compounds at different doses (20, 40 an...