The soluble copper silicate (CS) MIC of 100 strains of methicillin-resistant Staphylococcus aureus and 100 strains of methicillin-susceptible S. aureus (MSSA) was 175 mg Cu/liter. Bactericidal and postantibiotic effects (> or =1 h) were seen at 2x MIC and 4x MIC. The frequency of mutation was <10(-9), and serial passage could not extend growth beyond 1.6x MIC.

background: cefepime was used as empirical treatment in ventilator-associated pneumonia (vap) induced by gram-negative and gram-positive bacteria. this study aimed to determine the antimicrobial susceptibility pattern of cefepime against microorganism causing vap in mazandaran, north of iran. methods: this study was performed on vap patients diagnosed with clinical pulmonary infection score (cp...

The maximal information coefficient (MIC) is a tool for finding the strongest pairwise relationships in a data set with many variables [1]. MIC is useful because it gives similar scores to equally noisy relationships of different types. This property, called equitability, is important for analyzing high-dimensional data sets. Here we formalize the theory behind both equitability and MIC in the ...

LB 11058 is a novel parenteral cephalosporin with a C-3 pyrimidinyl-substituted vinyl sulfide group and a C-7 2-amino-5-chloro-1,3-thiazole group. This study evaluated the in vitro activity and spectrum of LB 11058 against 1,245 recent clinical isolates, including a subset of gram-positive strains with specific resistant phenotypes. LB 11058 was very active against Streptococcus pneumoniae. The...

The objective of the study was to analyze the vancomycin MIC distribution against bloodstream MRSA isolates for a period of 1 year in India. This retrospective study analyzed 71 blood stream MRSA strains isolated at a tertiary care hospital in India between January 2008 and December 2008. The vancomycin MIC was determined by broth microdilution method. Only one isolate per patient was analyzed....

ParC proteins. The results show that the use of 20 mg/L of Phe-Arg-β-naphthylamide decreased the MIC of nalidixic acid (from two to five serial twofold dilution steps) in all isolates tested, even in those with the nalidixic acid-susceptible phenotype. This high reduction in the MIC values was observed independent of the number of amino acid changes in GyrA and ParC. This effect was especially ...

During the last decade some studies have shown that the area under the curve (AUC)/MIC ratio is the pharmacodynamic index that best predicts the efficacies of quinolones, while other studies suggest that the predictive value of the peak concentration/MIC (peak/MIC) ratio is superior to the AUC/MIC ratio in explaining clinical and microbiological outcomes. In classical fractionated dose-response...