AIMS--To elucidate the fine specificities of the antibodies MIB 1 and MIB 3 and of additional monoclonal antibodies which also recognise the Ki-67 protein (MIB 5, IND.64, JG-67-2a). METHODS--Different parts of the Ki-67 protein cDNA were expressed in Escherichia coli. Bacterial lysates were separated by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and blotted on to nitr...

In humans, the single polymorphic B locus of the major histocompatibility complex is linked to the microsatellite MIB. In rhesus macaques, however, haplotypes are characterized by the presence of unique combinations of multiple B genes, which may display different levels of polymorphism. The aim of the study was to shed light on the evolutionary history of this highly complex region. First, the...

We observed a co-upregulation of the insulin-like growth factor receptor (IGF-1R)/AKT/mammalian target of rapamycin (mTOR) [InAT] axis and the mevalonate-isoprenoid biosynthesis (MIB) pathways in colorectal cancer stem cells (CSCs) in an unbiased approach. Hence, we hypothesized that the InAT axis might regulate the MIB pathway to govern colorectal CSCs growth. Stimulation (IGF-1) or inhibition...

This document defines a portion of the Management Information Base (MIB) for use with network management protocols in the Internet community. In particular, it describes objects for configuring parameters of the Neighborhood Discovery Protocol (NHDP) process on a router. The MIB module defined in this document, denoted NHDP-MIB, also reports state, performance information, and notifications abo...

We determined the concentrations of 2-methylisoborneol (2-MIB) and geosmin in final effluent from wastewater treatment plants Kyoto City, Japan, investigating variations during treatment. The 2-MIB were 5.1–29.8 3.9–13.9 ng/L, respectively. Geosmin primary higher than those influent. concentration increased reactors, while that decreased. anaerobic-anoxic-oxic step-feed biological nitrogen remo...

Motion in-betweening (MIB) is a process of generating intermediate skeletal movement between the given start and target poses while preserving naturalness motion, such as periodic footstep motion walking. Although state-of-the-art MIB methods are capable producing plausible motions sparse key-poses, they often lack controllability to generate satisfying semantic contexts required in practical a...

BACKGROUND A significant relationship has been reported in which Ki-67/MIB-1 expression is correlated with survival in cervical cancer patients. However, the prognostic value of Ki-67/MIB-1 in cervical cancer is still not well understood. MATERIAL AND METHOD A meta-analysis was carried out to explore the prognostic value of Ki-67/MIB-1 on overall survival (OS) and/or disease-free survival (DF...

The biological aggressiveness of lymph node-positive prostate cancer is closely linked to cancer volume in nodal metastases. We evaluated MIB-1 (Ki-67) labeling index and bcl-2 expression in primary cancer and matched nodal metastases from 138 node-positive patients treated with radical prostatectomy and bilateral pelvic lymphadenectomy between 1987 and 1992 at the Mayo Clinic. One hundred twen...

In this paper, we describe a non-adhoc approach to building an SNMP protocol object for the Protocol Independent Management Information Base (PIMIB). In [5], the design of a protocol independent MIB agent is proposed which can support both SNMPandCMIP.Then, in [9], we present the implementation of PIMIB, which provides not only management protocol independence (i.e., SNMP and CMIP) but also net...

BACKGROUND/AIMS Important characteristics of neuroendocrine neoplasms (NEN) for prognosis and therapeutic decisions are the MIB-1 proliferative index (tumor grade) and tumor stage. Moreover, these tumors express peptide hormone receptors like somatostatin and gastric inhibitory peptide (GIP) receptors which represent important established and potential future targets, respectively, for molecula...