نتایج جستجو برای: mhc دسته ii

تعداد نتایج: 617164  

Journal: :The Journal of Experimental Medicine 1992
C H Chang W L Fodor R A Flavell

Terminally differentiated plasma cells and mouse T cells do not express major histocompatibility complex (MHC) class II genes although class II gene expression is observed in pre-B and mature B cells as well as in activated human T cells. Transient heterokaryons were prepared and analyzed to investigate the mechanisms of inactivation of MHC class II gene in mouse plasmacytoma cells and mouse T ...

Journal: :Immunome Research 2009
Sune Justesen Mikkel Harndahl Kasper Lamberth Lise-Lotte B Nielsen Søren Buus

BACKGROUND Molecules of the class II major histocompability complex (MHC-II) specifically bind and present exogenously derived peptide epitopes to CD4+ T helper cells. The extreme polymorphism of the MHC-II hampers the complete analysis of peptide binding. It is also a significant hurdle in the generation of MHC-II molecules as reagents to study and manipulate specific T helper cell responses. ...

Journal: :The Journal of clinical investigation 1999
C Shi M W Feinberg D Zhang A Patel C U Sim Z M Dong S M Chapman J C Gutierrez-Ramos D D Wagner N E Sibinga E Haber

Transplant-associated arteriosclerosis remains an obstacle to long-term graft survival. To determine the contribution to transplant arteriosclerosis of MHC and adhesion molecules from cells of the donor vasculature, we allografted carotid artery loops from six mutant mouse strains into immunocompetent CBA/CaJ recipients. The donor mice were deficient in either MHC I molecules or MHC II molecule...

2016
Unni Grimholt

Major histocompatibility complex (MHC) molecules are key players in initiating immune responses towards invading pathogens. Both MHC class I and class II genes are present in teleosts, and, using phylogenetic clustering, sequences from both classes have been classified into various lineages. The polymorphic and classical MHC class I and class II gene sequences belong to the U and A lineages, re...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2009
Roger Belizaire Emil R Unanue

Peptides derived from exogenous proteins are presented by both MHC class I and II. Despite extensive study, the features of the endocytic pathway that mediate cross-presentation of exogenous antigens on MHC class I are not entirely understood and difficult to generalize to all proteins. Here, we used dendritic cells and macrophages to examine MHC class I and II presentation of hen egg-white lys...

2018
Joseph Yunis Helen E Farrell Kimberley Bruce Clara Lawler Stine Sidenius Orry Wyer Nicholas Davis-Poynter Philip G Stevenson

Cytomegaloviruses (CMVs) persistently and systemically infect the myeloid cells of immunocompetent hosts. Persistence implies immune evasion, and CMVs evade CD8+ T cells by inhibiting MHC class I-restricted antigen presentation. Myeloid cells can also interact with CD4+ T cells via MHC class II (MHC II). Human CMV (HCMV) attacks the MHC II presentation pathway in vitro, but what role this evasi...

Journal: :Journal of immunology 2009
Yan Qu Lakshmi Ramachandra Susanne Mohr Luigi Franchi Clifford V Harding Gabriel Nunez George R Dubyak

We recently reported that P2X7 receptor (P2X7R)-induced activation of caspase-1 inflammasomes is accompanied by release of MHC class II (MHC-II) protein into extracellular compartments during brief stimulation of murine macrophages with ATP. Here we demonstrate that MHC-II containing membranes released from macrophages or dendritic cells (DCs) in response to P2X7R stimulation comprise two pools...

2015
Kavita Purnanda Bhat KAVITA PURNANDA BHAT Susanna F. Greer

Major Histocompatibility Complex (MHC) class II molecules are indispensable arms of the immune system that present extracellular antigens to CD4 + T cells and initiate the adaptive immune response. MHC class II expression requires recruitment of a master regulator, the class II transactivator (CIITA). How this master transcriptional regulator is recruited, stabilized and degraded is unknown. Th...

Journal: :Journal of immunology 2013
Smita Srivastava Joel D Ernst

Effector T cells control intracellular infection by secreting cytokines and through contact-dependent cytolysis. Because cytokines can diffuse and act at a distance, we determined whether cytokine diffusion is sufficient to control Mycobacterium tuberculosis or whether direct recognition of infected cells by CD4 T cells is required. Using MHC class II (MHC II) mixed bone marrow chimeras, we com...

Journal: :Journal of immunology 2007
Alessandra De Riva Christine Bourgeois George Kassiotis Brigitta Stockinger

CD4 memory T cells surviving in the absence of MHC class II contact lose their characteristic memory function. To investigate the mechanisms underlying the impaired function of memory T cells in the absence of MHC class II molecules, we analyzed gene expression profiles of resting memory T cells isolated from MHC class II-competent or -deficient hosts. The analysis focused on five transcripts r...

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