INTRODUCTION Manual hyperinflation (MH), a maneuver applied in mechanically ventilated patients to facilitate secretion removal, has large variation in its performance. Effectiveness of MH is usually evaluated by its capacity to generate an expiratory flow bias. The aim of this study was to compare the effects of MH-and its resulting flow bias-applied according to clinical practice versus accor...

We have studied the ability of the calcium channel antagonist diltiazem to inhibit and reverse the porcine malignant hyperpyrexia (MH) syndrome. Pretreatment with diltiazem modified an MH response. Treatment with diltiazem was partially effective against a mild (or early) MH response. Diltiazem should not be considered to be an effective therapeutic agent for MH and should not displace the use ...

INTRODUCTION Manual hyperinflation (MH), a frequently applied maneuver in critically ill intubated and mechanically ventilated patients, is suggested to mimic a cough so that airway secretions are mobilized toward the larger airways, where they can easily be removed. As such, MH could prevent plugging of the airways. METHODS We performed a search in the databases of Medline, Embase, and the C...

BACKGROUND Malignant hyperthermia (MH), a pharmacogenetic disorder of skeletal muscle, presents with a potentially lethal hypermetabolic reaction to certain anesthetics. However, some MH-susceptible patients experience muscle weakness, fatigue, and exercise intolerance in the absence of anesthetic triggers. The objective of this exploratory study was to elucidate the pathophysiology of exercise...

Background: Severe hypothermia (SH, 30 C) increases the risk of pacing-induced ventricular fibrillation (PIVF) by enhancing spatially discordant alternans (SDA). Whether moderate hypothermia (MH, 33 C), which is clinically used for therapeutic hypothermia, also facilitates SDA remains unclear. We hypothesized that MH attenuates SDA occurrence compared with that achieved by SH, and decreases the...

BACKGROUND Masked hypertension (MH) is a relatively newly detected condition of which little is known. More information about MH may help to improve overall antihypertensive health care. We aimed to investigate the prevalence, potential causes, and associated consequences of MH. METHODS We searched published literature using MEDLINE, EMBASE, and the Cochrane database completed with references...

Maleic hydrazide (MH) is of practical and theoretical interest as a growth-regulating chemical that can inhibit plant growth without causing obvious morphological abnormalities (13, 14). After recent reports of growth interactions between MH and gibberellic acid (GA) (2, 10), Brian and Hemming called attention to the many growth effects for which MH has actions opposite to those of GA (1). From...

Katharina A. Sterenczak ([email protected]) Andre Eckardt ([email protected]) Andreas Kampmann ([email protected]) Saskia Willenbrock ([email protected]) Nina Eberle ([email protected]) Florian Länger ([email protected]) Sven Kleinschmidt ([email protected]) Marion Hewicker-Trautwein...