A new depot formulation of the LHRH analogue Zoladex (goserelin acetate) has been developed which releases the drug over a period of at least 3 months as judged by measurement of drug content in depots at intervals after insertion in male rats and by the suppression of oestrogen secretion and oestrus in female rats. This formulation is based on the lactide/glycolide polymer system used for the ...

BACKGROUND The size and geometry of an insulin depot that is formed during subcutaneous administration by an insulin pump is evaluated. A novel method is used to visualize accurately the depot formation for small volumes of insulin (of the order of 10-100 µl) at a given point in time. Conventional visualization methods such as magnetic resonance imaging are unable to provide such accurate measu...

Inspired by a real-life case in the Brussels Capital Region, Belgium, this paper provides Memetic Algorithm with Sequential Split procedure (MASS) for solving large variety of waste collection problems multiple depots, restricted vehicle fleet at each depot, (intermediate) processing facilities, capacity restrictions per facility and partial pick-ups. MASS first generates satisfactory initial s...

Nowadays, the majority of construction projects can be considered as complex and ambiguous endeavours. Each kind of construction project has its own characteristics and complexities whereas then specific management approaches and solutions are needed. Regarding the rapid development of cities, underground constructions at urban regions, such as metro construction, have been largely used for ext...

Ethernet has evolved from a local area to a wide area network technology. When it is used in a service provider environment, it has more complex requirements, which demand a set of management techniques for the Ethernet layer. Ethernet OAM comprises a set of management techniques for Carrier (or Metropolitan) Ethernet networks. Carrier Ethernet devices often have IP connectivity for management ...

In this article, we focus on the challenges and opportunities for broadband access deployment in India. We present an overview of the broadband scenario in India and the existing network architectures. We then review next generation technologies for broadband access including Metro Ethernet. We demonstrate how an optimal access architecture based on metro Ethernet can be developed for cost effe...

AIMS The aim was to assess the pharmacokinetics, pharmacodynamics, safety and tolerability of octreotide subcutaneous (s.c.) depot, a novel octreotide formulation. METHODS This was a phase I, randomized, open label study. After a single dose of octreotide immediate release (IR) 200 µg, subjects were randomized to one of eight groups to receive three monthly injections of octreotide s.c. depot...

Among numerous NP-hard problems, the Traveling Salesman Problem (TSP) has been one of the most explored, yet unknown one. Even a minor modification changes the problem’s status, calling for a different solution. The Generalized Traveling Salesman Problem (GTSP)expands the TSP to a much more complicated form, replacing single nodes with a group or cluster of nodes, where the objective is to fi...

Many fire evacuation models have been proposed in recent years to better simulate such as an emergency situation. However most of them do not respect a recommendation of fire evacuation experts regarding the fact that evacuees should follow the boundaries of obstacles or wall to find the exits when their visibility is limited by smoke. This paper presents an agent-based evacuation model with Sm...