To determine the contribution of metoclopramide to the efficacy of ondansetron in control of cisplatin-induced emesis, ondansetron was compared with ondansetron plus metoclopramide for antiemetic efficacy in a randomized double-blind trial. Enrolled 66 patients were treated with cisplatin(60mg/m2) in combination with etoposide, flourouracil, or vinblastine, and randomized to receive either onda...

The investigation examines the hypothesis that metoclopramide-induced potentiation of gastrointestinal motility is mediated through dopamine receptors. In vitro studies on the longitudinal muscle of the guinea-pig ileum were performed. Metoclopramide, in concentrations comparable with those seen in plasma after therapeutic doses in man, selectively potentiated the cholinergic response Dopamine ...

OBJECTIVE A double-blind, multicenter, randomized trial was conducted to compare the side effects and efficacy of domperidone and metoclopramide in symptomatic diabetic gastroparesis. METHODS Ninety-three insulin-dependent diabetes patients with a > or = 3-month history of gastroparesis symptoms were recruited; 48 received domperidone 2 x 10-mg tablets 4 times daily, and 45 received metoclopr...

3 McCallum RW, Kline MM, Curry N, Sturdevant RAL. Comparative efforts of metoclopramide and bethanechol on lower esophageal sphincter pressure in reflux patients. Gastroenterology 1975;68:1 114-8. McCallum RW, Berkowitz DM. The frequency of delayed gastric emptying in patients with gastroesophageal reflux and its response to metoclopramide and bethanechol. Gastroenterology 1978 ;74:1135. Gugler...

Background/Aim—The eVects of diVerent prokinetic agents, the motilide erythromycin and the substituted benzamides metoclopramide and cisapride, were investigated in a rat model of postoperative ileus. These eVects were compared with that of granisetron, a 5-hydroxytryptamine (5-HT3) receptor antagonist, and a novel enterokinetic agent, prucalopride, a 5-HT4 receptor agonist. Methods—DiVerent de...

BACKGROUND/AIM The effects of different prokinetic agents, the motilide erythromycin and the substituted benzamides metoclopramide and cisapride, were investigated in a rat model of postoperative ileus. These effects were compared with that of granisetron, a 5-hydroxytryptamine (5-HT(3)) receptor antagonist, and a novel enterokinetic agent, prucalopride, a 5-HT(4) receptor agonist. METHODS Di...

Metoclopramide was described in 1964 as an anti-emetic drug and stimulant of gastrointestinal motility. Dopamine D2 receptor antagonism explained the anti-emetic activity and was suggested to stimulate gastrointestinal motility. An important use of metoclopramide and other D2 receptor antagonists is to inhibit emesis caused by anticancer chemo radiotherapy. However, the use of new platinum-base...

Metoclopramide is a dopamine antagonist in the central nervous system and an antiemetic agent. It can cause extrapyramidal symptoms side effects such as dystonic reactions characterized by involuntary, sustained or spasmodic contractions of muscle groups, resulting twisting, repetitive abnormal postures. In this study, we aimed to report pediatric patient who presented with acute dystonia due m...

The symptoms of hyperprolactinemia in women mainly result from changes in the release of gonadotropins and the consequent repercussions on ovarian function. Metoclopramide is a hyperprolactinemic drug that is used as an antiemetic agent. In female mice, metoclopramide-induced hyperprolactinemia causes changes in the reproductive system, mainly in ovarian function and the endometrium. While ther...