Chemotherapy induced nausea and vomiting (CINV) are two of the most feared adverse events experienced by cancer patients undergoing chemotherapy. Metoclopramide was derived from procainamide in the 1950s and one of the first drugs investigated in the prophylaxis of nausea and vomiting induced by chemotherapy. The breakthrough came in 1981 with the recognition that high-dose metoclopramide was e...

When memories are retrieved, they can enter a labile state during which the memory may be modified and subsequently restabilized through the process of reconsolidation. However, this does not occur in all situations, and certain "boundary conditions" determine whether a memory will undergo reconsolidation. Naïve male lister hooded rats were trained for 5 days to press a lever in order to retrie...

ascorbic acid (vitamin c) supplementation has been documented as a useful tool to improve the performance of laying birds reared under harsh environmental conditions. however, there is limited information on the use of ascorbic acid as a means of ameliorating the stressful conditions imposed by feed restriction. to this effect a 3 × 2 factorial experiment was carried out to evaluate the effect ...

We aimed to evaluate macrophages heterogeneity and structural, functional and inflammatory alterations in rat kidney by aldosterone + salt administration. The effects of treatment with spironolactone on above parameters were also analyzed. Male Wistar rats received aldosterone (1 mgkg-1d-1) + 1% NaCl for 3 weeks. Half of the animals were treated with spironolactone (200 mg kg-1d-1). Systolic an...

UNLABELLED The effects of metoclopramide on the central nervous system (CNS) in patients suggest substantial brain distribution. Previous data suggest that metoclopramide brain kinetics may nonetheless be controlled by ATP-binding cassette (ABC) transporters expressed at the blood-brain barrier. We used (11)C-metoclopramide PET imaging to elucidate the kinetic impact of transporter function on ...

abstract with increasing population, mine activities for metal proceeding are also increasing, so environment will be influenced by contaminant especially heavy metals. in situ immobilization of heavy metals using inexpensive amendments is considered as a simple and cost-effective approach for reducing heavy metal contamination. in this research we used sequential extraction for assessing reduc...

This study was undertaken to compare the induction characteristics of conventional thiopentone sodium, midazolam, and a combination of midazolam and thiopentone sodium as co-induction agent. Total one hundred and fifty patients of ASA grade I and II were divided into three groups in a double blind randomized study. Group-I received midazolam 0.25 mgkg-1 intravenously, group–II received thiopent...

The prokinetic effect of metoclopramide is mediated through the blockade of enteric (neuronal and muscular) inhibitory dopamine D2 receptors, and metoclopramide has the ability to stimulate 5-HT3 and 5-HT4 receptors (2). Metoclopramide also exerts inhibitory effects on D2 receptors centrally (located outside the blood-brain barrier), and these contribute to its antiemetic effect. Metoclopramide...

Abstract Objectives We analysed 900 samples of fresh (250) and processed (650) fish products collected in Sicily (Southern Italy) 2020 during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic (hereafter: COVID-19). Materials methods The were divided temporally based on five phases relating to various restrictions imposed by Italian government this period. validated metho...