BACKGROUND Emergency Department (ED) headache patients are commonly treated with neuroleptic antiemetics like metoclopramide. Haloperidol has been shown to be effective for migraine treatment. STUDY OBJECTIVE Our study compared the use of metoclopramide vs. haloperidol to treat ED migraine patients. METHODS A prospective, double-blinded, randomized control trial of 64 adults aged 18-50 year...

OBJECTIVE A double-blind, multicenter, randomized trial was conducted to compare the side effects and efficacy of domperidone and metoclopramide in symptomatic diabetic gastroparesis. METHODS Ninety-three insulin-dependent diabetes patients with a > or = 3-month history of gastroparesis symptoms were recruited; 48 received domperidone 2 x 10-mg tablets 4 times daily, and 45 received metoclopr...

3 McCallum RW, Kline MM, Curry N, Sturdevant RAL. Comparative efforts of metoclopramide and bethanechol on lower esophageal sphincter pressure in reflux patients. Gastroenterology 1975;68:1 114-8. McCallum RW, Berkowitz DM. The frequency of delayed gastric emptying in patients with gastroesophageal reflux and its response to metoclopramide and bethanechol. Gastroenterology 1978 ;74:1135. Gugler...

BACKGROUND In this prospective, randomized, double-blind study, we compared the efficacy of ondansetron versus dehydrobenzoperidol (droperidol) or metoclopramide in the treatment of established postoperative nausea and vomiting in 200 adult patients undergoing laparoscopic surgery under general anesthesia. METHODS One hundred seventy-three American Society of Anesthesiologists (ASA) I and II ...

Metoclopramide is a dopamine antagonist in the central nervous system and an antiemetic agent. It can cause extrapyramidal symptoms side effects such as dystonic reactions characterized by involuntary, sustained or spasmodic contractions of muscle groups, resulting twisting, repetitive abnormal postures. In this study, we aimed to report pediatric patient who presented with acute dystonia due m...

The symptoms of hyperprolactinemia in women mainly result from changes in the release of gonadotropins and the consequent repercussions on ovarian function. Metoclopramide is a hyperprolactinemic drug that is used as an antiemetic agent. In female mice, metoclopramide-induced hyperprolactinemia causes changes in the reproductive system, mainly in ovarian function and the endometrium. While ther...

BACKGROUND Metoclopramide is a centrally acting antiemetic and ketamine is a general anesthetic used with sedatives, tranquilizers and analgesics. Metoclopramide has analgesic effects and its combination with ketamine causes sedation and hypnosis. The contribution of metoclopramide to the analgesic effect of ketamine is not known. The purpose of the present study was to explore the analgesic ef...

To the Editor: In the otherwise excellent review article "Anaesthesia and emesis, II" by Palazzo and Strunin, ~ the section devoted to metoclopramide is perhaps open to comment. Reference is made to Davies and Howells' paper on the ability of metoclopramide to empty the stomach following injury, 2 which did not differentiate between liquid and solid gastric content. Hancock 3 showed no differen...