A 26-year-old woman 3 months post-partum was admitted to our hospital suffering from gross visual disturbance. Magnetic resonance imaging (MRI) revealed a pituitary mass, extending into the suprasellar cistern, with intense gadolinium enhancement. Lymphocytic hypophysitis (LHy) was suspected, and the patient received high dose methylprednisolone pulse therapy (HDMPT). Her visual disturbance was...

REJECTION CONTINUES TO BE A MAJOR PROBLEM confronting the transplant recipient and his surgeon. Acute reject,ion of renal allografts is commonly treated by increasing the daily oral dose of corticosteraids. Multiple complications of this therapy, including gastrointestinal hemorrhage and increased susceptibility to infection, have been reported. Intermittent large-dose intravenous corticosteroi...

Background Mycoplasma pneumoniae (M. pneumoniae) pneumonia is one of the most common causes of community acquired pneumonia in children. The clinical course is usually self limited and benign. But rarely severe pneumonia could be complicated despite appropriate antibiotic therapy. We determine the impact of methylprednisolone pulse therapy on the severe refractory M. pneumoniae pneumonia in chi...

Intravenous methylprednisolone pulse therapy in a reduced dose of 10 mg/kg on three consecutive days was successfully used in the treatment of a 9 year old girl with acute cerebral lupus in coma. It is recommended for further evaluation in children with severe primary central nervous system (CNS) disease.

RATIONALE Treatment choices are limited, when deciding how to manage thyrotoxicosis and moderate to severe Graves ophthalmopathy (GO) with suspected optic nerve damage in patients with elevated liver transaminase levels. The situation become even more complicated, if methimazole induced hepatotoxicity is suspected and intravenous methylprednisolone is co-administrated. PATIENT CONCERNS A 74-y...

The efficacy and safety, including arrhythmia and sudden death, 2 of intravenous methylprednisolone pulse (IVMP) therapy in patients with Kawasaki disease (KD) are uncertain. We conducted a control study in KD patients with persistent or recurrent fever (>37.5̊ C) 48 hours after a single infusion of initial intravenous immunoglobulin (IVIG) 2 g/kg. At enrolment (day 1), the subjects were randomi...

The deleterious effects of corticosteroids (CS) on bone are well known, but probably differ depending on duration and dosage of CS therapy. Presently huge amounts of CS are given over a short period of time in different rheumatic conditions. Not much is known about the effect of this kind of CS treatment on bone metabolism. Twenty patients with persistently active rheumatoid arthritis were trea...

A recent paper described a randomised comparative study of intravenous (IV) pulse methylprednisolone versus infliximab treatment in patients for whom methotrexate treatment had failed. The conclusions that infliximab treatment offered substantial benefits over IV methylprednisolone may be correct, but the design of the trial has resulted in a biased assessment in favour of IV infliximab treatme...

A 65-year-old man was diagnosed with granulomatosis with polyangiitis (GPA) based on the detection of high myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA), vasculitis and granulomas in a lung biopsy specimen and crescentic glomerulonephritis in a kidney biopsy specimen. Soon after the initiation of intravenous methylprednisolone pulse therapy (mPSL pulse) and intravenous cycloph...