Photodynamic therapy (PDT) is a therapeutic modality with significant antimicrobial activity. We present 2 cases of chronic lower limb ulcers in which fungal and bacterial superinfection complicated management. PDT with methylene blue as the photosensitizer led to clinical and microbiological cure with no significant adverse effects. PDT with methylene blue is a valid option for the management ...

Oral treatment with ifosfamide results in dose-limiting encephalopathy. Methylene blue is effective in reversal and prophylaxis of this side effect. In the present study, the pharmacokinetics of ifosfamide after iv and po therapy in combination with prophylactic administration of methylene blue were investigated. Nine patients with metastatic non-small cell lung cancer were treated by a combina...

Communications to the Editor tolmetric analysis) is elevated. Severe methemoglobinemia is rapidly reversed by intravenous administration (If the reducing agent methylene blue (1-2 mg/kg in a 1 percent solution administered over 5 min).23 Because of the urgency (If treating severe methemoglobinemia, particularly in patients who have underlying lung disease, bronchocopists are well advised to mai...

The photo-oxidation of lysozyme (hen’s egg white), sensitized by methylene blue in 84% acetic acid solution, causes the selective modification of the methionyl residues, which are converted to the sulfoxide. The photo-oxidized protein shows a drastically reduced enzymic activity. The data obtained by comparing the sensitivity to proteolytic enzymes, as. well as the accessibility of disulfide bo...

The aim of this study was to evaluate the effects of the laser radiation (685 nm) associated with photosensitizers on viability of different species of Candida genus. Suspensions of Candida albicans, Candida dubliniensis, Candida krusei and Candida tropicalis, containing 10(6) viable cells per milliliter were obtained with the aid of a Neubauer's chamber. From each species, 10 samples of the ce...

Methylene blue is a safe and effective therapeutic agent used in a variety of different clinical settings, including as treatment for methemoglobinemia, reversing ifosfamide-induced encephalopa-thy, severe hepatopulmonary syndrome, and as a pressor during catecholamine-refractory septic shock (1). Of more relevance to neuropathologists, it has recently been experimentally tested as a dye in mul...

The time of administration has varied from 24 hours to 5 weeks before delivery,2 and in most cases exchange transfusion or phototherapy, or both, was required to control the jaundice. In 2 cases respiratory distress was reported as well3 4 although it is difficult to determine whether or not this was related to the dye. In this case the L/S ratio at the time of amniocentesis was 2-4. Although m...

The objective of this study was to measure discolouration using a digital camera on various types of clear orthodontic elastic modules, immersion solutions, and time periods to determine whether the cause of discolouration of these modules was due to simple staining, chemical degradation, or both. Three types of clear orthodontic elastomeric modules were investigated [Plastic ligatures (AO); Po...

Hydrogen peroxide is an important mild oxidant which is widely used in various applications including remediation of waste waters and drinking water resources. The safe level of H2O2 residue has to be controlled through accurate and precise measurement methods. A facile spectrophotometric method for the determination of hydrogen peroxide is based on the reaction of iodine ...