نتایج جستجو برای: methyl palmitate

تعداد نتایج: 114555  

2018
Ben D Perry Jill A Rahnert Yang Xie Bin Zheng Myra E Woodworth-Hobbs S Russ Price

Saturated fatty acids, such as palmitate, are elevated in metabolically dysfunctional conditions like type 2 diabetes mellitus. Palmitate has been shown to impair insulin sensitivity and suppress protein synthesis while upregulating proteolytic systems in skeletal muscle. Increased sarco/endoplasmic reticulum (ER) stress and subsequent activation of the unfolded protein response may contribute ...

Journal: :The Biochemical journal 1964
S Mahadevan D S Deshmukh J Ganguly

Irrespective of the form of vitamin A fed to rats, it appears in blood almost exclusively as retinyl palmitate, and the liver always stores only this ester. Differences in the fatty acid composition of the dietary fats do not seem to have any influence on the type of retinyl ester absorbed and stored by the rat (Mahadevan & Ganguly, 1961; Mahadevan, Seshadri Sastry & Ganguly, 1963). It was ther...

2015
Xin Tong Deqiang Zhang Blake Arthurs Pei Li Leigh Durudogan Neil Gupta Lei Yin Nicolas Cermakian

Elevated levels of serum saturated fatty acid palmitate have been shown to promote insulin resistance, increase cellular ROS production, and trigger cell apoptosis in hepatocytes during the development of obesity. However, it remains unclear whether palmitate directly impacts the circadian clock in hepatocytes, which coordinates nutritional inputs and hormonal signaling with downstream metaboli...

Journal: :The Journal of biological chemistry 2006
Eamon P Breen Sebastien G Gouin Andrew F Murphy Lee R Haines Angela M Jackson Terry W Pearson Paul V Murphy Richard K Porter

Native uncoupling protein 1 (UCP 1) was purified from rat mitochondria by hydroxyapatite chromatography and identified by peptide mass mapping and tandem mass spectrometry. Native and expressed UCP 1 were reconstituted into liposomes, and proton flux through UCP 1 was shown to be fatty acid-dependent and GDP-sensitive. To investigate the mechanism of action of UCP 1, we determined whether hydro...

Journal: :American journal of physiology. Endocrinology and metabolism 2010
Larysa Yuzefovych Glenn Wilson Lyudmila Rachek

The type of free fatty acids (FFAs), saturated or unsaturated, is critical in the development of insulin resistance (IR), since the degree of saturation correlates with IR. We compared the effects of the saturated FFA palmitate, the unsaturated FFA oleate, and a mixture of each on the production of mitochondrial reactive oxygen species (mtROS), mitochondrial DNA (mtDNA) damage, mitochondrial fu...

Journal: :Journal of molecular and cellular cardiology 1996
S Abdel-aleem M A Nada M Sayed-Ahmed S C Hendrickson J St Louis H P Walthall J E Lowe

The regulation of fatty acid oxidation in isolated myocytes was examined by manipulating mitochondrial acetyl-CoA levels produced by carbohydrate and fatty acid oxidation. L-carnitine had no effect on the oxidation of [U-14C]glucose, but stimulated oxidation of [1-14C]palmitate in a concentration-dependent manner. L-carnitine (5 mM) increased palmitate oxidation by 37%. The phosphodiesterase in...

Journal: :American journal of physiology. Endocrinology and metabolism 2009
Hakam Alkhateeb Adrian Chabowski Jan F C Glatz Brendon Gurd Joost J F P Luiken Arend Bonen

We examined whether AICAR or leptin rapidly rescued skeletal muscle insulin resistance via increased palmitate oxidation, reductions in intramuscular lipids, and/or restoration of insulin-stimulated AS60 phosphorylation. Incubation with palmitate (2 mM, 0-18 h) induced insulin resistance in soleus muscle. From 12-18 h, palmitate was removed or AICAR or leptin was provided while 2 mM palmitate w...

Journal: :American journal of physiology. Endocrinology and metabolism 2008
Jonathan M Peterson Yan Wang Randall W Bryner David L Williamson Stephen E Alway

Insulin resistance is a primary characteristic of type 2 diabetes. Several lines of evidence suggest that accumulation of free fatty acids in skeletal muscle may at least in part contribute to insulin resistance and may be linked to mitochondrial dysfunction, leading to apoptosis. Palmitate treatment of several cell lines in vitro results in apoptosis and inhibits protein kinase B (Akt) activit...

To assess different effects of royal Jelly in protecting the human endothelial cells from high glucose level, human umbilical vein endothelial cells were exposed to various concentrations of royal jelly, from 0.625 to 10 mg/ml, at the presence of 5 and 30 mM glucose contents over a course of 72 h. In addition to cell viability assessment by conventional MTT assay, we also analyzed the feature o...

Journal: :Canadian journal of physiology and pharmacology 2009
Kristin D Hauff Seok-Yong Choi Michael A Frohman Grant M Hatch

We examined whether cardiolipin (CL) synthesis was required to support cholesterol (CH) production from palmitate in Hela cells. Knockdown of human cardiolipin synthase-1 (hCLS1) in Hela cells has been shown to reduce CL synthesis. Therefore Hela cells stably expressing shRNA for hCLS1 and mock control cells were incubated for 16 h with [14C(U)]palmitate bound to albumin (1:1 molar ratio) in th...

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