Metastatic disease accounts for more than 90% of cancer-related deaths, but the development of effective antimetastatic agents has been hampered by the paucity of clinically relevant preclinical models of human metastatic disease. Here, we report the development of a mouse model of spontaneous breast cancer metastasis, which recapitulates key events in its formation and clinical course. Specifi...

OBJECTIVE The purpose of this study is to review our series of metastatic basal cell carcinomas of the head and neck. STUDY DESIGN A retrospective review was conducted for this study. METHODS All cases of documented metastatic basal cell carcinomas arising from a primary within the head and neck region and presenting for treatment to one of the authors (Y.D.) were included in this review. ...

The cover image is based on the Research Article Sex, racial/ethnic and socioeconomic disparities in patients with metastatic bone disease by Muhammad Umar Jawad MD et al., https://doi.org/10.1002/jso.26765

Metastatic bone disease is the most common malignancy involving bone. The skeleton is the third most frequent organ involved by metastatic tumors and comes after lungs and liver in the list (Coleman, 2006). Most of the metastatic tumors are carcinomas and rarely sarcomas. Different studies have shown that 30-90% patients of common carcinomas have skeletal metastasis in their course of disease. ...

Here, we describe a patient with a history of colorectal cancer in whom 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography ([18F]FDG PET/CT) was performed for the evaluation of response to therapy. [18F]FDG PET/CT showed a small residual disease in the rectum. In addition, multiple metabolically inactive soft tissue densities were d...

INTRODUCTION AND OBJECTIVES Metastatic Crohn's disease (MCD) is an extraintestinal manifestation of Crohn's disease, with biopsy as fundamental diagnostic tool. There are few references to MCD in children, with a 0.5-1% estimated incidence in adults. There is no consensus about its therapeutic approach. We describe our diagnostic and therapeutic experience in MCD. RESULTS Four cases of MCD ar...

The incidence of primary cancer increases with each passing year, and patients are living longer as a result of improved therapies and interdisciplinary management. Consequently, long-term complications such as debilitating spinal metastases are becoming more prevalent. In this review, the mechanism of metastasis, clinical presentation, and imaging modalities are briefly summarized. Then, vario...

BACKGROUND Gastric metastases are rare and represent a late and progressed stage of malignant disease. This review highlights epidemiological, clinical and endoscopic findings as well as therapeutic strategies for metastatic disease of the stomach. SUMMARY The clinical presentation of gastric metastases is highly unspecific. The endoscopic appearance of gastric metastases is heterogeneous, bu...

Objective(s): Small cell lung cancer (SCLC) is an aggressive neuroendocrine carcinoma, which accounts for 10-15% of pulmonary cancers and exhibits early metastatic spread. This study aimed to determine the added value of 18F-FDG PET/CT imaging in tumor, node, and metastasis (TNM) staging of SCLC, compared to the conventional computed tomography (CT) scan and its potential role as a prognosticat...

Ten patients received liver transplants for unresectable epithelioid hemangioendothelioma (EHE). At the time of transplantation, four patients had microscopic metastases to the hilar lymph nodes, and one of the four also had metastases to a rib. The fifth patient had metastases to the lung, pleura, and diaphragm. The remaining five patients were believed to be free of metastatic disease. Two of...