blood pressure 85/105 mmHg urinary metanephrines 4.21 μmol/24 h (0.00–1.20) MIBG scan 2.6 cm right tracer-avid adrenal mass ultrasound scan of abdomen likely cyst in head of pancreas measuring 46 mm, with three small simple cysts measuring 7 mm, 8 mm and 6.5 mm in tail of pancreas. Normal size and appearance of kidneys, small 4 mm mid/upper pole cortical cyst on the right side, no hydronephrosi...

1. A new, specific and sensitive urinary assay for separate normetanephrine (NM) and separate metanephrine (M) is described. 2. This test employs high-voltage paper electrophoresis after passage of the urine through a resin column. 3. There is no difference in the urinary excretions of either separate NM or separate M in normotensive or hypertensive subjects. 4. Phaeochromocytoma patients excre...

Nitisinone blocks the tyrosine pathway and may be effective in treating neuroblastoma. A 33-month-old male with heavily treated metastatic, recurrent, N-MYC amplified neuroblastoma received nitsinone (0.8 mg/kg/day escalated to 5.0 mg/kg/day). Dramatic tumor regression and resolution of pain without toxicity were observed. At 10 weeks, the tumor progressed. Nitisinone, low dose cyclophosphamide...

Pheochromocytoma is an endocrine tumor classically presenting with headache, paroxysmal hypertension, and palpitations. We discuss the case of a young male, presenting with acute heart failure and cardiogenic shock requiring stabilization with an intra-aortic balloon pump and a combination of ionotropes and vasopressors. Pheochromocytoma was diagnosed by CT scan, as well as urine and plasma met...