DNA damage elicits a cellular signaling response that initiates cell cycle arrest and DNA repair. The metabolic response to DNA damage is largely unknown. Here we report a novel metabolic response to genotoxic stress. DNA damage triggers a critical block in the uptake of glutamine, a mitochondrial substrate essential for cellular proliferation. Sirtuins regulate both cellular metabolism and str...

In the last years, a great effort has been made to unify different independent colorectal cancer (CRC) molecular classification systems into four consensus subtypes (CMS). The are found be associated with distinct microenvironmental features and clinical outcome, although metabolic singularities not well established. Metabolic dysregulation reported as hallmark of CMS3 but heterogeneity among o...

Hypothalamic proopiomelanocortin (POMC) neurons are critical for controlling homeostatic functions in mammals. We used a transgenic mouse model in which the POMC neurons were labeled with enhanced-green fluorescent protein (EGFP) to perform visualized, whole-cell patch recordings from pre-pubertal female hypothalamic slices. The mouse POMC-EGFP neurons expressed the same endogenous conductance ...

This review considers the potential utility of positron emission tomography (PET) tracers in the setting of response monitoring in breast cancer, with a special emphasis on glucose metabolic changes assessed with (18)F-fluorodeoxyglucose (FDG). In the neoadjuvant setting of breast cancer, the metabolic response can predict the final complete pathologic response after the first cycles of chemoth...

It is becoming apparent that is patients with hirsutism, metabolic aberrations are of greater health importance rather than unwanted hair growth.in this respect , evaluation of carbohydrate and lipid metabolism was carried out on a group of 92 women with idiopathic hirsutism(IH).these were divided into: obese and non-profit obese  groups.seventy healthy subjects were also taken as control group...

We compared morphologic computed tomography (CT)-based to metabolic fluoro-deoxy-glucose (FDG) positron emission tomography (PET)/CT-based response evaluation in patients with metastatic colorectal cancer and correlated the findings with survival and KRAS status. From 2006 to 2009, patients were included in a phase II trial and treated with cetuximab and irinotecan every second week. They under...

Viruses, including human cytomegalovirus (HCMV), reprogram cellular metabolism using host metabolic regulators to support virus replication. Alternatively, in response infection, the can use limit

The immediate local metabolic response of the myocardium to acute regional ischemia is determined by an interaction of various influences. These include: (1) the extent of and the variability in reduction of blood flow; (2) the degree and persistence of hypoxia; and (3) the effects of local release of catecholamines, particularly in relation to loss of intracellular potassium. The subsequent me...