نتایج جستجو برای: mesna

تعداد نتایج: 2537  

Journal: :Biochemical Society transactions 1990
J J Turner C A Rice-Evans M J Davies E S Newman

established, the mechanism by which /?-carotene exerts a protective function against cancer remains unknown. However, there are several lines of evidence which suggest that the generation of reactive oxygen species may play an important role in the development of cancer [14]. The present work emphasizes that attention should be extended from /?-carotene to lycopene and other carotenoids. Lycope...

Journal: :Medico-Legal Update 2021

Background: Synovial sarcoma mediastinum is a rare tumor, with few cases having been reported.Case Presentation: A 27-year-old Indonesian woman had complaint of shortness breath and left chestpain. Chest X-ray showed massive pleural effusion reddish-yellow fluid. Thorax CT scanshowed clear demarcated mass in the anterior until medius, value lactic aciddehydrogenase 561 U/L. The patient was diag...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2002
Peter D Sadowitz Bradley A Hubbard James C Dabrowiak Jerry Goodisman Kirk A Tacka Mehmet K Aktas Mary J Cunningham Ronald L Dubowy Abdul-Kader Souid

DNA platination by cisplatin (CDDP) was investigated in peripheral blood mononuclear cells and ovarian cancer cells using atomic absorption spectroscopy. Plots showing the amount of platinum (Pt) bound to DNA versus the molar concentration of cisplatin in the incubation medium ([CDDP]) were nonlinear. For [CDDP] < about 5 microM, the amount of Pt bound to DNA increased slowly with added drug. H...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Janelle B Perkins Steven C Goldstein Jana L Dawson Jongphil Kim Teresa L Field James S Partyka Karen K Fields Beth L Maddox Christine E Simonelli Anthony M Neuger Richard M Lush Daniel M Sullivan

PURPOSE To determine the maximum tolerated dose (MTD) of topotecan in combination with ifosfamide, mesna, and etoposide (TIME), followed by autologous hematopoietic cell transplant (HCT), in patients with chemotherapy-refractory malignancies. EXPERIMENTAL DESIGN Patients were treated with (in mg/m(2)/d) ifosfamide 3,333, mesna 3,333, and topotecan 3.3 to 28.3 during days -8 through -6 and eto...

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