We report the first case of methaemoglobinaemia induced by mesalazine. A woman suffering diarrhea and abdominal pain was initially treated with sulfamethoxazole–trimethoprim (TMP–SMX) and metronidazole for suspected infectious colitis. The treatment was stopped after ten days and she was referred to a gastroenterologist. A colonoscopy showed features resembling inflammatory bowel disease. Histo...

1. Ford AC, Achkar JP, Khan KJ, et al. Efficacy of 5-aminosalicylates in ulcerative colitis: systematic review and meta-analysis. Am J Gastroenterol. 2011;106:601-616. 2. Ford AC, Khan KJ, Talley NJ, Moayyedi P. 5-aminosalicylates prevent relapse of Crohn’s disease after surgically induced remission: systematic review and meta-analysis. Am J Gastroenterol. 2011;106:413-420. 3. Ford AC, Kane SV,...

BACKGROUND Post-infectious irritable bowel syndrome (PI-IBS) due to traveler's diarrhea is the second most common illness seen in post-travel clinics, yet its optimal management remains unknown. We performed a systematic review to evaluate treatment efficacy in PI-IBS. METHODS We searched Medline, EMBASE, LILACS, CINAHL, CAB abstracts, and the Cochrane Library to February 3, 2014 for interven...

BACKGROUND Environmental enteric dysfunction (EED) is an acquired syndrome of impaired gastrointestinal mucosal barrier function that is thought to play a key role in the pathogenesis of stunting in early life. It has been conceptualized as an adaptive response to excess environmental pathogen exposure. However, it is clinically similar to other inflammatory enteropathies, which result from bot...

BACKGROUND Mesalazine (mesalamine) (5-ASA) is considered an anti-inflammatory drug for the treatment of inflammatory bowel disease. It is well tolerated by most patients and induces mucosal healing specifically in ulcerative colitis. Besides its anti-inflammatory properties, 5-ASA has been studied for cancer inhibitory activities as it seems to reduce colorectal cancer incidence in patients usi...

Sirs, Churg-Strauss syndrome (CSS) is a rare disorder characterized by asthma, eosinophilia and systemic vasculitis (1). Three different phases can usually be recognized in CSS: asthma and atopic allergies such as rhinitis may precede of months, and sometimes of several years, the development of an eosinophilic infiltrative disease with eosinophilic pneumonia or gastro-enteritis followed by the...

Background: US and European guidelines recommend budesonide for the treatment of mild-to-moderate active ileocolic Crohn’s disease (CD). However, budesonide has not been approved, and mesalazine is widely used as first-line treatment in Japan. The objective of this study was to evaluate the efficacy and safety of budesonide in patients with mild-to-moderate active CD in Japan. Methods: In this ...

BACKGROUND A loss of intestinal glycosaminoglycans (GAGs) has been shown in inflammatory bowel diseases (IBD). Since GAGs are involved in the regulation of renal protein filtration and GAGs disruption is associated with anionic proteinuria, we examined whether changes in the selectivity of renal protein filtration occur in IBD. METHODS From 46 patients with IBD (17 with Crohn's disease (CD), ...

RATIONALE Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease, are associated with a large number of extraintestinal manifestations. Pulmonary manifestations are infrequently seen in patients with IBD. Moreover, serositis including pleural and pericardial manifestations in UC is rare. PATIENT CONCERNS We report a case of UC with acute pleurisy in a 43-year...