Use of the lowest clinically effective dose of postmenopausal hormone therapy conforms to current recommendations and good clinical practice. Although accumulating evidence demonstrates the efficacy and tolerability of low hormone therapy doses, data about their use are limited by a lack of long-term, randomized studies. This review evaluates current evidence on the efficacy, safety, and tolera...

Much of the research involving soyfoods published over the past 20 years, especially the clinical research (human intervention studies), has focused on the health of postmenopausal women. This focus is understandable because soyfoods are uniquely rich sources of isoflavones. Soybean isoflavones are commonly referred to as phytoestrogens (plant estrogens). Clinical research indicates that isofla...

There is accumulating evidence but no definitive answers about the incidence of depressed mood in the menopause transition and its association with the changing hormonal milieu. While a changing hormonal milieu is the natural condition for all women, only a minority of mid-life women experience debilitating depressive symptoms or clinical depression. This review focuses on associations between ...

OBJECTIVE Hot flashes are a significant problem in women going through the menopausal transition that can substantially affect quality of life. The world of estrogen therapy has been thrown into turmoil with the recent results of the Women's Health Initiative trial report. Pursuant to a growing interest in the use of alternative therapies to alleviate menopausal symptoms and a few pilot trials ...

BACKGROUND To assess the prevalence of menopausal symptoms among women prescribed hormone therapy (HT) using electronic medical record data from a regional healthcare organization. METHODS Retrospective data from the Reliant Medical Group from 1/1/2006-12/31/2011 were assessed for 102 randomly-selected patients. Study eligibility criteria included: females aged 45 to 65; prescribed oral or tr...

BACKGROUND Typical menopause-related symptoms sometimes mimic cardiovascular illnesses or other physical problems. It is essential to understand the help-seeking behaviors of menopausal women. METHODS A total of 181 subjects were recruited from our menopause-related mood clinic. A questionnaire which included patient data and help-seeking questions was used. All help-seeking information was d...

Title: Effect of soy lecithin on fatigue and menopausal symptoms in middle-aged women: a randomized, double-blind, placebo-controlled study Authors: Asuka Hirose (a-kacrm@tmd.ac.jp) Masakazu Terauchi (teragyne@tmd.ac.jp) Yurika Osaka (120122ms@tmd.ac.jp) Mihoko Akiyoshi (akiyoshi@shonan.bunkyo.ac.jp) Kiyoko Kato (kiyoko2226@nifty.com) Naoyuki Miyasaka (n.miyasaka.gyne@tmd.ac.jp) Version: 2 Date...

OBJECTIVE This study aims to determine the prevalence and severity of menopausal symptoms in older postmenopausal women and, hence, the need for treatment options for women of this age. METHODS This is a cross-sectional questionnaire-based study conducted between October 2013 and March 2014 among 2,020 women aged 40 to 65 years and living independently across Australia. The main outcome measu...

Extracts from Cimicifuga racemosa (CR, synonym Actaea racemosa) have shown efficacy in trials in women with menopausal symptoms. Yet, dose dependency remains unclear. Therefore, 180 female outpatients with climacteric complaints were treated for 12 weeks in a randomized, double-blind, placebo-controlled, 3-armed trial (CR extract Ze 450 in 6.5 mg or 13.0 mg, or placebo). Primary outcome was the...