Abstract In Chapter 8, we introduced mathematical models of the action potential across a cell membrane. Understanding properties membrane is absolutely essential in order to understand electrophysiology excitable cells. However, some can only be studied spatially resolved models; i.e., representing spatial variation single or collection

Breast cancer has become common in developing and developed countries. Alarming increase in this disease as a leading cause of death in women is a concern of all. Despite the significant improvements in the management of breast cancer, the survival rate is not more than 20% - 25%. For this study, MDA-MB231 cell line was used and the effect of ICD-85 (biologically active peptides from venomous ...

background: type-i diabetes is an autoimmune inflammatory disease in which pancreatic ß-cells are selectively destroyed by infiltrating cells. tnf-related apoptosis-inducing ligand (trail) is a type-ii membrane protein of the tnf superfamily which is expressed in different tissues, including pancreas and lymphocytes. in humans, trail interacts with four membrane receptors. trail-r1 and trail-r2...

Glycosaminoglycans (GAGs) are long and unbranched anionic heteropolysaccharides that have been associated with virtually all amyloid deposits. Soluble sulfated GAGs known for their propensity to promote the self-assembly of numerous amyloidogenic proteins modulate cytotoxicity. Nonetheless, although prevalent on outer leaflet eukaryotic cell plasma membrane as part proteoglycans, contributions ...

Glioma is the most common primary tumor of central nervous system. Currently, there no effective treatment for glioma. Melittin (MT) main component bee venom, which was found to have therapeutic effects on a variety tumors. In this study, we explored relationship between key genes regulated by MT and prognosis cultured glioma U87 U251 cells, inhibited cell proliferation induces apoptosis in tim...

Background: Stem cell therapy for the treatment of vascular-related diseases through functional revascularization is one of the most important research areas in tissue engineering. The aim of this study was to investigate the in vitro differentiation of umbilical CL-MSC into endothelial lineage cells. Methods: In this study, isolated cells were characterized for expression of MSC-specific marke...

3450 bovine from different breeds and ages were clinically examined for the presence of arthritis. 120 cases showed macroscopic evidences of arthritis. mycoplasma spp were isolated from synovial fluid of 21 affected animals. in addition to mycoplasma spp. arcanobacterium pyogenes and staphylococcus epidermidis were isolated from 2 cases. the synovial fluid was markedly increased, straw color, t...

Cell membrane has a critical and vital role in functioning and existence of nerve cells that form central nervous system (CNS) in mammals. Disruption of nerve membrane that normally occurs following an accident injuring spinal cord is known to be the major cause of paralysis. In most occasions, spinal cord injuries are not leading to complete cut in spinal cord fibers but are known to cause cru...