Hurdwau has obtained a certain amount of unenviable notoriety on account of the outbreaks of cholera, which are supposed to have originated there during great fairs, and been thence spread far and wide by the pilgrims on the return journey to their homes. On this account the following notes on Hurdwar cholera may be of interest. Before narrating the particulars of the outbreak of this year, I w...

We herein report a rare case of MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes) and diabetes mellitus with ketoacidosis. An 18-year-old female patient was diagnosed to have diabetes mellitus and insulin therapy was thereafter initiated. At 26 years of age, she was hospitalized for diabetic ketoacidosis, soon followed by a loss of consciousness, left-side...

The pathogenetic mechanism of the mitochondrial tRNA A3243G transition associated with the mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome has been investigated in transmitochondrial cell lines constructed by transfer of mutant mitochondrial DNA (mtDNA)-carrying mitochondria from three genetically unrelated MELAS patients or of isogenic wild-ty...

This article is a brief account of a rare Urdu booklet entitled 'Report Nizam Ayurvedic Safari Dawakhana'. It is a report of a mobile clinic sent by Nizam VII of Hyderabad to Kumbh Mela at Allahabad on a religious occasion in the year 1942, which was printed in the same year. This report sheds light on the history of the sacred place Prayag, its importance and the activities of the mobile clini...

OBJECTIVE To report an unusual presentation of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) manifested in late life with a clinical picture of herpes simplex encephalitis. DESIGN Case report. SETTING Clinical neurology department in a tertiary care hospital. CASE DESCRIPTION A 55-year-old woman developed aphasia and delirium during ophthalmic herpes z...

With interest we read Finsterer et al.'s response [1] to our manuscript ‘Case Report: 5 Year Follow-Up of Adult Late-OnsetMitochondrial Encephalomyopathy with Lactic Acid and Stroke-Like Episodes (MELAS)’ [2]. We have the following responses: Regarding the lack of theMRIfigure, theMRIwas performed at an outside hospital. As a result an MRI figure was not available despite efforts to the contrar...

Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like episodes (MELAS) is a rare mitochondrial disorder. Diagnostic criteria for MELAS include typical manifestations of the disease: stroke-like episodes, encephalopathy, evidence of mitochondrial dysfunction (laboratorial or histological) and known mitochondrial DNA gene mutations. Clinical features of MELAS are not necessaril...

INTRODUCTION Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) is a rare, neurodegenerative and fatal disease caused by mutations in the mitochondrial DNA. Multiple systems of the body, including the oral cavity, can be affected by this disease. An electronic search of Medline spanning the years 1985 to 2003 was carried out using the key words "MELAS, Dent...

BACKGROUND AND PURPOSE The precise mechanism of neurological symptoms with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS) is still controversial. We investigated the correlation between strokelike episodes and cerebral blood flow in two patients with MELAS and discuss the pathogenesis of strokelike episodes with MELAS. SUMMARY OF REPORT Cerebral dynam...