Objective
 To evaluate tear functions and Meibomian glands’
 status in patients with cutaneous rosacea.
 Material Methods
 Right eyes of 38 rosacea
 (study group) 30 healthy volunteers (control
 were evaluated. After Ocular Surface Disease
 Index (OSDI) score was calculated, osmolarity
 break-up time (T-BUT) measured, and
 the Schirmer test applied r...

PURPOSE To prospectively evaluate the effect of topical diquafosol sodium on eyes with dry eye disease (DED) and meibomian gland dysfunction (MGD). PATIENTS AND METHODS The subjects were consecutive patients diagnosed with both DED and MGD at Inouye Eye Hospital between March and September of 2016. The subjects were administered topical 3% diquafosol sodium ophthalmic solution six times a day...

Pterygium is a very common disease in an eye clinic characterized by a benign proliferation of local conjunctiva that often crosses the limber of cornea and extends into corneal surface. Variety of studies has showed that pterygium is able to result in ocular discomfort and the change of ocular surface environment, such as dry eye. However, the link between abnormal tear film function and ptery...

BACKGROUND The tear film lipid layer is formed from lipids secreted by meibomian glands of the eyelid. After initial analyses of these lipids we concluded that an understanding of the function of the various classes of lipids in a normal lipid layer could only be understood after detailed investigations of both polar and nonpolar lipids of the meibomian gland. METHODS Meibomian gland secretio...

PURPOSE To determine the location of parasympathetic neurons that innervate the meibomian glands in rats. METHODS The B subunit of cholera toxin (CTB), fast blue, and a retrograde transneuronal tracer, the Bartha strain of pseudorabies virus (PRV-Ba), were injected into the upper eyelids of adult Sprague-Dawley rats after sectioning the ipsilateral branches of the facial nerve and resecting t...

Purpose To establish a simplified three-dimensional (3D) meibomian gland culture model using a meibomian gland epithelial cell (HMGEC) line that might be a useful tool to gain deeper insights into meibomian gland dysfunction. For this purpose, 3D differentiation patterns and growth characteristics of HMGECs were studied on various membranes/scaffolds as well as in hanging drops. Methods Sever...

Meibomian gland dysfunction (MGD) is the most frequent cause of dry eye disease (DED). Eyelid inflammation, microbial growth, associated skin disorders as well as potentially severe corneal complications culminate to make MGD a complex multifactorial disorder. It is probable that MGD is a heterogeneous condition arising from any combination of the following five separate pathophysiological mech...

To overcome the limitation of artificial judgment of meibomian gland morphology, we proposed a solution based on an improved fuzzy c-means (FCM) algorithm and rough sets theory. The rough sets reduced the redundant attributes while ensuring classification accuracy, and greatly reduced the amount of computation to achieve information dimension compression and knowledge system simplification. How...

PURPOSE To describe lipid-induced specific videokeratographic (VKG) corneal changes and subsequent resolution after eyelid washing. METHODS VKG was performed with C-Scan corneal topography. In all patients an excessive meibomian gland lipid secretion was found with or without coexistent chronic posterior blepharitis. After the initial VKG, a meticulous cleaning of the lids with a mild alkali ...