نتایج جستجو برای: medulloblastoma radiotherapy
تعداد نتایج: 67113 فیلتر نتایج به سال:
medulloblastoma is one of the most common primary tumors of the central nervous system of children but it is uncommon in adult age. we report a case of young male presented with a history of generalized headache that was found to have medulloblastoma with diffuse leptomeningeal involvement without prominent mass lesion. to our knowledge, our patient is the second reported case of medulloblastom...
Medulloblastoma is a pediatric brain tumor with a variable prognosis due to clinical and genomic heterogeneity. Among the 4 major genomic sub-groups, patients with MYC amplified tumors have a particularly poor prognosis despite therapy with surgery, radiation and chemotherapy. Targeting the MYC oncogene has traditionally been problematic. Here we report that MYC driven medulloblastoma can be ta...
Abstract BACKGROUND Cranial irradiation as part of prophylactic (PCI) or radical treatment for childhood malignancies can be associated with late consequences such radiotherapy induced meningioma. METHODS We are reporting 5 patients treated at our institute. RESULTS Case 1: 24y female received PCI Acute Lymphoblastic Leukemia the age 2, and developed right frontal meningioma which was resected ...
Medulloblastoma epitomizes the war against childhood cancer. Although this small round blue-cell tumor accounts for only 20% of all childhood brain tumors, or just fewer than 600 new cases each year in the United States, medulloblastoma has nevertheless become a paradigm for biologic study, clinical investigation, and assessment of late effects. Craniospinal irradiation historically became the ...
BACKGROUND The effect and possible timing of nonradiolabeled somatostatin analogue octreotide are still not determined in the treatment of medulloblastoma, while the presence of somatostatin receptor type-2 (SSTR2) is proved in the majority of medulloblastoma by several authors. PROCEDURES Daoy, SSTR2A positive medulloblastoma cell culture was tested with octreotide in monotherapy and combine...
We previously showed the involvement of the tyrosine kinase receptor c-Met in medulloblastoma malignancy. The nonreceptor tyrosine kinases focal adhesion kinase (FAK) and Pyk2 are key players in the progression of different cancers. However, their role in medulloblastoma malignancy is not well understood. In this study, using a protein array approach, we found that c-Met induces FAK and Pyk2 ph...
Treatment for medulloblastoma during childhood impairs neurocognitive function in survivors. While those diagnosed at younger ages are most vulnerable, little is known about the long-term neurocognitive, functional, and physical outcomes in survivors as they approach middle age. In this retrospective cohort study, we assessed 20 adults who were treated with surgery and radiotherapy for medullob...
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