The pore domain of voltage-gated potassium (Kv) channels consists of transmembrane helices S5 and S6, the turret, the pore helix, the selectivity filter, and the loop preceding S6, with a tertiary reentrant structure between S5 and S6. Using biogenic intermediates, mass tagging (pegylation), and a molecular tape measure, we explored the possibility that the first stages of pore formation occur ...

Public spending on healthcare has increased significantly over the past five years. One way to assess the benefits of such spending is to look at how well trusts can convert the increased resources into improved healthcare outcomes. This article reviews a number of suggested approaches to measuring performance in the UK’s NHS and provides an illustrative analysis of the efficiency of the so-cal...

regarding to rapidly changing and highly competitive business environment it will become increasingly important for organizations to measure their performances appropriately. with respect to special characteristics of pharmaceutical industry and lack of reported performance measurement, this study tries to design an integrated performance measurement model for pharmaceutical companies. for gene...

The 4.2 Berkeley Software Distribution of UNIX® for the VAX‡ had several problems that could severely affect the overall performance of the system. These problems were identified with kernel profiling and system tracing during day to day use. Once potential problem areas had been identified benchmark programs were devised to highlight the bottlenecks. These benchmarks verified that the problems...

A horizontal fragment of a database class in an object-oriented database system contains subsets of its instance objects (or class extents) reeecting the way applications are accessing database objects. Allocating well-deened fragments of classes to distributed sites has the advantage of minimizing transmission costs of data to remote sites as well as minimizing retrieval time of data needed lo...