Measles morbillivirus is regarded as one of the most influential contagious virus in timeline human history. Before classification this and formulation early vaccines starting 1960s, it was responsible for killing 0.1 – 10 % every birth cohort. While live-attenuated samples measles have considerably mitigated fatality rate around 99% developed states, - 1 million fatalities are nevertheless occ...

In 2007 eight epidemic clusters (more than 15 cases in each) and other sporadic cases of measles occurred in Hokkaido district, Japan. A total of 850 cases were identified. Approximately half of them were > or = 15 years of age, resulting in a huge public health problem in the community associated with school closings, and 31% of the cases reported that they already had a history of vaccination...

OBJECTIVE The clinical differential diagnosis of rash due to viral infections is often difficult, and misdiagnosis is not rare, especially after the introduction of measles and rubella vaccination. A study to determine the etiological diagnosis of exanthema was carried out in a group of children after measles vaccination. METHODS Sera collected from children with rash who received measles vac...

BACKGROUND: Although an effective measles vaccine has been available for almost 40 years, in 2000 there were about 30 million measles infections worldwide and 777,000 measles-related deaths. The history of smallpox suggests that achieving measles eradication depends on several factors; the biological characteristics of the organism; vaccine technology; surveillance and laboratory identification...

This study sought to investigate persistent measles virus infection of the intestine: a novel protocol for immunogold electron microscopy was developed using a polyclonal anti-measles nucleoprotein antibody on reprocessed, formalin fixed paraffin wax embedded tissue sections. Antibody binding was detected using both immunoperoxidase and light microscopy on tissue sections, and 10 nm gold conjug...

Measles is a highly contagious respiratory virus infection, with typical clinical symptoms including maculopapular rash, fever, cough, coryza, and conjunctivitis. Despite implementation of widespread vaccination programs throughout the world, the rates of global morbidity and mortality are still considerable. This study was performed to design a reliable indirect enzyme-linked immunosorbent ass...

Genetic characterization of wild-type measles viruses provides a means to study the transmission pathways of the virus and is an essential component of laboratory-based surveillance. Laboratory-based surveillance for measles and rubella, including genetic characterization of wild-type viruses, is performed throughout the world by the WHO Measles and Rubella Laboratory Network, which serves 166 ...

Following their initial isolation in cell culture of the virus in 1954, a succession of investigators under the mentorship of John E Enders conducted the research, development, and initial clinical studies responsible for the licensure in 1963 of a successful live attenuated measles virus vaccine. Propagation of the virus successively in human kidney cells, human amnion cells, embryonated hens'...

Gamma interferon (IFN-γ) plays an important role in the immune response to live measles virus vaccination. To study the immune response to measles vaccination, IFN-γ level was estimated in 30 children. Of these, 24 children vaccinated with a single dose of measles vaccine at nine months of age and 06 children vaccinated with a second dose during the Measles Catch-up Immunization campaign. Measl...

The role of the immune response to measles virus in acute infection or in disease states associated with this virus is of major interest. The viral genome-specified surface antigens of measles, the hemagglutinin and fusion proteins, are likely to be of paramount importance with respect to the host immune response to the virus. This report describes initial studies aimed at assessing the immune ...