This report describes a measles outbreak in a rural town in south-east Queensland and presents the results of a vaccine effectiveness (VE) study performed during this outbreak. It is important to assess the effectiveness of a vaccine in an outbreak to determine if the outbreak is due to failure of the vaccine or failure to vaccinate. There were 44 cases of measles amongst local residents, which...

Before rubella vaccine was introduced for schoolgirls and susceptible women in 1970, 200-300 babies were born annually in England and Wales with congenital defects associated with maternal rubella. In 1988 the combined measles, mumps, and rubella vaccine was introduced for all 1 year olds; in 1994, to help avert a predicted measles epidemic, all 5-16 year olds were offered combined measles and ...

BACKGROUND Due to intensified measles immunization efforts, measles mortality has decreased substantially worldwide, particularly in Sub-Saharan Africa (SSA). The World Health Organization (WHO) estimated a 92% decrease in measles-related deaths in the WHO AFRO region for the period 2000-2008. Recently, the AFRO region established a measles pre-elimination goal and experts have suggested engagi...

Measles vaccination is estimated to have averted 13·8 million deaths between 2000 and 2012. Persisting heterogeneity in coverage is a major contributor to continued measles mortality, and a barrier to measles elimination and introduction of rubella-containing vaccine. Our objective is to identify determinants of inequities in coverage, and how vaccine delivery must change to achieve elimination...

In 1995, as part of its measles control programs, the National Advisory Council on Immunization recommended the use of the trivalent measles-mumps-rubella vaccine (MMR) for the second measles vaccination. However, the Mumps and Rubella Consensus Conference demonstrated that mumps are considered a very low-priority disease in Canada and a single-dose vaccination program seems acceptable. Since t...

BACKGROUND According to WHO estimates, 35% of global measles deaths in 2011 occurred in India. In 2013, India committed to a goal of measles elimination by 2020. Laboratory supported case based measles surveillance is an essential component of measles elimination strategies. Results from a case-based measles surveillance system in Pune district (November 2009 through December 2011) are reported...

Abstract Despite the availability of a safe and effective vaccine, measles still causes significant mortality morbidity among children in developing countries. As disease that induces immune amnesia with increased susceptibility to other infections but also life-long immunity measles, little is known about immunogenetics B cells elicit measles-specific antibodies (Abs) natural infection vs vacc...

We describe the occurrence of measles in an 18 month-old patient in Sicily, Italy, in March 2015, who received the first dose of a measles-containing vaccine seven days before onset of prodromal symptoms. Measles virus infection was confirmed by PCR and detection of specific immunoglobulin; viral genotyping permitted the confirmation of a vaccine-associated illness. The patient had a concurrent...

OBJECTIVE The clinical differential diagnosis of rash due to viral infections is often difficult, and misdiagnosis is not rare, especially after the introduction of measles and rubella vaccination. A study to determine the etiological diagnosis of exanthema was carried out in a group of children after measles vaccination. METHODS Sera collected from children with rash who received measles vac...

BACKGROUND Measles was eliminated in the United States through high vaccination coverage and a public health system able to rapidly respond to measles. Measles may occur among vaccinated individuals, but secondary transmission from such individuals has not been documented. METHODS Suspected patients and contacts exposed during a measles outbreak in New York City in 2011 were investigated. Med...