Hematological and biochemical reference values in sickle cell disease (SCD) are crucial for patient management the evaluation of interventions. This study was conducted at Muhimbili National Hospital (MNH) Dar es Salaam, Tanzania, to establish laboratory ranges among children adults with SCD steady state. Patients were grouped into five age groups according their sex. Aggregate functions used h...

Prevention of erythrocyte dehydration is a potential therapeutic strategy for sickle cell disease. Increasing erythrocyte magnesium (Mg) could inhibit sickle cell dehydration by increasing chloride (CI) and water content and by inhibiting potassium chloride (K-CI) cotransport. In transgenic SAD 1 and (control) C57BL/6 normal mice, we investigated the effect of 2 weeks of diet with either low Mg...

The purpose of this experiment was to determine the effects of high environmental temperature on the blood indices (mean corpuscular volume, MCV; mean corpuscular hemoglobin, MCH; mean corpuscular hemoglobin concentration, MCHC) of Thai Indigenous Chickens (TIC), Thai Indigenous Chickens Crossbred (TICC) and broilers (BC). One kilogram of male and female TIC, TICC and BC were maintained in an e...

Nitric oxide (NO), essential for maintaining vascular tone, is produced from arginine by nitric oxide synthase. Plasma arginine levels are low in sickle cell anemia, and it is reported here that low plasma arginine is also found in our sickle transgenic mouse model that expresses human alpha, human beta(S), and human beta(S-Antilles) and is homozygous for the mouse beta(major) deletion (S+S-Ant...

The recent reports of the effect of 2,3-diphosphoglycerate (2,3-DPG) on hemoglobin affinity for oxygen suggested that this substance may play a role in man's adaptation to acidosis and alkalosis.A study of the effect of induced acidosis and alkalosis on the oxyhemoglobin dissociation curve of normal man was therefore carried out, and the mechanisms involved in the physiological regulation of he...

The purpose of this study was to evaluate cytologically the bone marrow (and peripheral blood) of adult laying hens affected with lymphoid leukosis. Diagnosis of the neoplasm was made on the basis of clinical history, signs and symptoms and pathology. Only histologically confirmed cases were included in the study. Examination of blood smears revealed +2 heterophil toxicity and the presence of l...

Monogeneans are the parasites mostly found on the body surface and gills of fish and can cause large losses in farmed fish. Some studies demonstrate elevated parasitic levels causing hematological alterations. But few of them relate the effects of parasitism on the hematology and histopathology of native freshwater farmed fish. This study evaluated the host-parasite relationship in pacu (Piarac...

The effect of fresh, photo-activated and distilled cow urine was examined on the hematological parameters pathogen-induced albino rats using automated analyzer. were grouped into 3 (A, B C) 2 controls; with each group containing 5 rats. Each animal induced 0.5mL Pseudomonas aeruginosa, Escherichia coli Salmonella typhi respectively. After 7 days infection, treated for period days. infected P. a...

Sickle cell disease (SCD) is an inherited blood disorder that affects red cells. The study was conducted in Elobied town during the period May 2011 to September 2011. aim of this detect abnormalities leucocytes among sickle anemic patients. 40 patients; age range between 8 months 23 years. Blood sample taken for all patients and laboratory investigation were performed using automated estimation...

Hematology is an important pathological and diagnostic tool. This paper describes the hematological parameters of 76 specimens of Hoplias malabaricus infested with monogenean parasites, which were collected from two lagoons. The hematological parameters included: erythrocyte count (Er), microhematocrit (Hct), hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and ...