Methyl-coenzyme M reductase (MCR) is a nickel tetrahydrocorphinoid (coenzyme F430) containing enzyme involved in the biological synthesis and anaerobic oxidation of methane. MCR catalyzes the conversion of methyl-2-mercaptoethanesulfonate (methyl-SCoM) and N-7-mercaptoheptanoylthreonine phosphate (CoB7SH) to CH4 and the mixed disulfide CoBS-SCoM. In this study, the reaction of MCR from Methanot...

Results The MCR sheets manufactured with a shore hardness of 15’ Shore ‘A’, has helped prevent high pressure points and thus avoid plantar ulcers in anaesthetic feet. Natural Rubber along with several other chemicals is used in optimum quantities to manufacture MCR. The unique manufacturing process gives MCR the ability to spring back to original shape when pressure is released while walking. T...

We report here a new type of plasmid that carries the mcr-1 gene, the pMCR-1-P3 plasmid, harbored in an Escherichia coli strain isolated from a pig farm in China. pMCR-1-P3 belongs to the IncY incompatibility group and is a phage-like plasmid that contains a large portion of phage-related sequences. The backbone of this plasmid is different from that of other mcr-1-carrying plasmids reported pr...

Methyl-coenzyme M reductase (MCR) from methanogenic archaea catalyzes the rate-limiting and final step in methane biosynthesis. Using coenzyme B as the two-electron donor, MCR reduces methyl-coenzyme M (CH3-SCoM) to methane and the mixed disulfide, CoBS-SCoM. MCR contains an essential redox-active nickel tetrahydrocorphinoid cofactor, Coenzyme F430, at its active site. The active form of the en...

To the editor: The foregoing letter by Lentz et al. examined the occurrence of the mcr-1 gene in Escherichia coli isolates recovered from chicken cloacal swabs collected between August and October of 2015, from a poultry slaughterhouse in southern Brazil [1], providing valuable additional data on the epidemiology of this novel gene. Of 343 animals screened, 10 (3%) different chickens belonging ...

BACKGROUND Chronotropic incompetence (CI), an attenuated heart rate (HR) response to exercise, is common in patients with cardiovascular disease. The aim of this study was to assess changes in the chronotropic response (CR) during cardiopulmonary exercise testing (CPET) in patients undergoing cardiac rehabilitation and investigate the effects of β-blockers. METHODS Patients undergoing cardiac...

Background: Currently, colistin-resistant pathogens emerged has become a global health concern. This study assessed the distribution of mcr-1 to mcr-5 variants with phenotypic colistin-resistance in bacterial isolates from urinary tract infection (UTI) patients Bangladesh.Methods: A cross-sectional was conducted between April 2017 and March 2018 enroll uncomplicated UTI patients, 142 urine samp...