Description/Mechanism of Action Recombinant human parathyroid hormone (rhPTH 1-84) is identical to endogenous parathyroid hormone (PTH) and binds PTH-1 receptors in the bone, kidney, and has an indirect effect on calcium reabsorption in the intestine. It increases serum calcium by increasing renal tubular calcium reabsorption, intestinal calcium absorption, and bone turnover. Indication under R...

The efficient formation of 5-methylcytosine glycol (mCg) and its facile deamination to thymine glycol (Tg) may account for the prevalent C → T transition mutation found at methylated CpG site (mCpG) in human p53 gene, a hallmark for many types of human tumors. In this work, the hydrolytic deamination of mCg was investigated at the MP2 and B3LYP levels of theory using the 6-311G(d,p) basis set. ...

Report of three cases of chylothorax and one case of chylous ascites in children who had undergone cardiac surgery with no response to routine clinical treatment, based on fasting and long-term parenteral nutrition. Treatment with octreotide at an initial dose of 1.0 mcg/kg/h was chosen, with a gradual increase of 1.0 mcg/kg/hr/day until a maximum dose of 4.0 mcg/kg/h. All cases had a favorable...

With the proposition of a Markov chain random field (MCRF) theory and its accompanying spatial measure – the transiogram, Markov chain has been extended into a nonlinear Markov chain-based geostatistical approach for one to multi-dimensional conditional (or unconditional) simulation, called Markov chain geostatistics (MCG). This new approach has nonlinear estimators, considers conditional indep...

Let G be a connected, simply-connected, simple affine algebraic group and Cg be a smooth irreducible projective curve of any genus g ≥ 1 over C. Denote by MCg (G) the moduli space of semistable principal G-bundles on Cg. Let Pic(MCg (G)) be the Picard group of MCg (G) and let X be the infinite Grassmannian of the affine Kac-Moody group associated to G. It is known that Pic(X) ≃ Z and is generat...

We set up an electronic gradiometer for magnetocardiography (MCG) in an unshielded environment. The electronically balanced gradiometer consists of high-temperature radio-frequency superconducting quantum interference device (rf SQUID) magnetometers. The rf SQUID magnetometers are arranged to form the electronic first-order, four-vector gradiometer, or second-order gradiometer. The output of th...

This paper presents a heuristic cost minimization approach to synthes­ izing linear reversible circuits. Two bidirectional linear reversible circuit syn­ thesis methods are introduced, the Alternating Elimination with Cost Minimiza­ tion method (AECM) and the Multiple CNOT Gate method (MCG). Al­ gorithms, example syntheses, and extensions to these methods are presented. An MCG variant which inc...

In this paper, a new approach is presented for the assessment of a 3-D anatomical and functional model of the heart including structural information from magnetic resonance imaging (MRI) and functional information from positron emission tomography (PET) and magnetocardiography (MCG). The method uses model-based co-registration of MR and PET images and marker-based registration for MRI and MCG. ...

We report on 64 patients who did not achieve erections adequate for satisfactory sexual intercourse from among a total of 243 patients who were prescribed PDE5 inhibitors for erectile dysfunction (ED). Intracavernous injection (ICI) of PGE was performed in this non-responder group. An ICI of 20 or 40 mcg of PGE1 in 1 ml saline was performed and the responses evaluated. Forty-nine out of 64 (77 ...