نتایج جستجو برای: mcf 7 cell line

تعداد نتایج: 2482554  

2015
Faeze Vali Vahid Changizi Majid Safa

Background. Chemotherapy, radiotherapy, and surgery are routine treatments of breast cancer. However, these methods could only improve the living survival. Nowadays the combined therapy including herbals such as crocin is to study for improving breast cancer treatment. The purpose of this study was to evaluate the effects of crocin, paclitaxel, and radiation on MCF-7 cell. Methods. To evaluate ...

Journal: :Molecules 2016
Yao Wei Mingzhen Li Shufang Cui Dong Wang Chen-Yu Zhang Ke Zen Limin Li

Shikonin is a naphthoquinone isolated from the traditional Chinese medicine Lithospermum. It has been used in the treatment of various tumors. However, the effects of shikonin on such diseases have not been fully elucidated. In the present study, we detected the exosome release of a breast cancer cell line (MCF-7) with shikonin treatment and found a positive relationship between the level of se...

2015
Katarína Koňariková Miriam Ježovičová Ján Keresteš Helena Gbelcová Zdeňka Ďuračková Ingrid Žitňanová

In this study we investigated effects of natural extract from the black tea Camellia sinensis (BTE) against human colon carcinoma cell line HT-29, human breast carcinoma cell line MCF-7, human alveolar carcinoma cell line A549 and healthy cell line NIH-3T3. We identified concentration range for cytotoxic/antiproliferative effects using MTT assay and the trypan blue assay, gel electrophoresis we...

Journal: :modares journal of medical sciences: pathobiology 2012
karim khoshgard bijan hashemi azim arbabi mohammad javad rasaee masoud soleimani

objective: due to recent advances in nanotechnology it is now possible to accumulate high atomic-number nanomaterial such as gold nanoparticles (gnps) in cancerous cells and take advantage of their absorbed dose enhancement property as radiosensitizing agents. this study aimed to investigate the absorbed dose enhancement factor due to the presence of pegylated gnps under the irradiation of an m...

Journal: :International journal of molecular medicine 2007
Paola Poma Monica Notarbartolo Manuela Labbozzetta Annamaria Maurici Valeria Carina Alessandra Alaimo Michele Rizzi Daniele Simoni Natale D'Alessandro

We examined the effects of curcumin and of its isoxazole analogue MR 39 in the MCF-7 breast cancer cell line and in its multidrug-resistant (MDR) variant MCF-7R. In comparison with MCF-7, MCF-7R lacks estrogen receptor alpha (ERalpha) and overexpressess P-glycoprotein (P-gp), different IAPs (inhibitory of apoptosis proteins) and COX-2. Through analyses of the effects on cell proliferation, cycl...

Journal: :Brazilian Journal of Pharmaceutical Sciences 2023

Paclitaxel (PTX) is one of the most effective drugs used in treatment breast cancer. Nonetheless, appearance MDR1 (multidrug resistance 1) tumor cells has become a significant hindrance for efficacious chemotherapy. In this study, we show that expression level Egr-1 (early growth response gene-1) cancer tissues (from paclitaxel chemotherapy failure patients) and MCF-7/PTX (the cell line was res...

Journal: :Cancer research 1997
A S Levenson V C Jordan

On Thursday,January2, 1997, Dr. HerbertSoule, the scientist who developed the MCF-7 breast cancer cell line, died. At the time, we were in the process of writingthis tributeto markthe 25th anniversary of Dr. Soule's remarkableaccomplishment.The cells, derived from a breast cancer patient in the Detroit area and developed at the Michigan CancerFoundation,Detroit,became a standardmodel in hundred...

Journal: :Anticancer research 2012
Marianna Trebunova Galina Laputkova Eva Slaba Kamila Lacjakova Aneta Verebova

BACKGROUND Cell viability assays are important tools in oncological research. The purpose of this study was to evaluate the effect of docetaxel, doxorubicin and cyclophosphamide on the metabolic activity of MCF-7 breast cancer cell line. MATERIALS AND METHODS Antiproliferative effect of cytostatics on MCF-7 cells was measured using the standard colorimetric test. The MCF-7 cell line was expos...

Journal: :iranian biomedical journal 0
محمد هاشمی mohammad hashemi فاطمه کرمی تهرانی fatemeh karami-tehrani سعید قوامی saeed ghavami

cladribine, an analogue of deoxyadenosine, is highly toxic for both non-dividing and proliferating cells and has shown activity in the treatment of several malignancies. therefore, the aim of the present study is to investigate the cytotoxicity effect of cladribine (2-cda) on the breast cancer cell line, mcf-7 (estrogen receptor positive, er+). mtt assay, annexin v-fluorescein/pi and hoechst 33...

Journal: :jundishapur journal of natural pharmaceutical products 0
hadi kalantar department of pharmacology, school of medicine, shahid beheshti university of medical sciences, tehran, ir iran masoumeh sabetkasaei department of pharmacology, school of medicine, shahid beheshti university of medical sciences, tehran, ir iran ali shahriari department of biochemistry, school of veterinary medicine, shahid chamran university, ahvaz, ir iran mostafa haj molla hoseini department of immunology, school of medicine, shahid beheshti university of medical sciences, tehran, ir iran siavash mansouri department of internal of medicine, faculty of medicine, saarland university of medical center, homburg, germany mojtaba kalantar department of toxicology, school of medicine, ahvaz jundishapur university of medical sciences, ahvaz, ir iran

conclusions these outcomes support our theory that rapamycin increases oxidative stress in mcf-7 and mda mb-231 cells but also shows high levels of antioxidant effects, which probably limit the effects of the rapamycin on the same issue in the clinic. methods the mcf-7 and mda mb-231 cell lines were cultivated and treated with rapamycin for 72 hours. the viability of the cells was determined us...

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