The human cytomegalovirus (HCMV)-encoded cyclin-dependent kinase (CDK) ortholog pUL97 associates with human cyclin B1 and other types of cyclins. Here, the question was addressed whether cyclin interaction of pUL97 and additional viral proteins is detectable by mass spectrometry-based approaches. Proteomic data were validated by coimmunoprecipitation (CoIP), Western blot, in vitro kinase and bi...

The dispersion and dilution of contrast medium through the myocardial vasculature is examined first with a serial model comprised of arterial, capillary, and venous components in series to determine their time-concentration curves (TCC) and the myocardial dilution curve (MDC). Analysis of general characteristics shows that the first moment of the MDC, adjusted for that of the aortic TCC and mea...

Several studies indicate that immune responses are markedly depressed early after onset of hemorrhage. Decreased organ blood flow has been implicated in the pathophysiology of altered immune responses after trauma-hemorrhage. In this regard, administration ofl-arginine has been shown to restore depressed intestinal and hepatic blood flow after trauma-hemorrhage, probably due to provision of sub...

Shear rate is significantly lower in the superficial femoral compared with the brachial artery in the supine posture. The relative shear rates in these arteries of subjects in the upright posture (seated and/or standing) are unknown. The purpose of this investigation was to test the hypothesis that upright posture (seated and/or standing) would produce greater shear rates in the superficial fem...

MBV acknowledges support from Juan de la Cierva Formacion fellowship program (FJCI-2018-036520-I) Spanish Ministry of Science. B.V. and R.S have been funded by PR01018-EC-H2020-FETOpen MADONNA project. R.S. also counted with the Santa Fe Institute, Secretaria d’Universitats i Recerca del Departament d’Economia Coneixement Generalitat Catalunya. FTM European Research Council grant agreement no 6...

Purpose Historically, assessments of myocardial perfusion have relied heavily on measurements of myocardial blood flow (MBF). However, because only ~50% of capillaries are functional at rest [1], the recruitment of capillaries, or changes in myocardial blood volume (MBV), may also play a significant role in supplying O2 to the myocardium [2]. Our MRI methods can quantify MBF, MBV, oxygen extrac...

Abstract. This paper presents a new edge-swap heuristic for generating spanning trees with a minimum number of branch vertices, i.e. vertices of degree greater than two. This problem was introduced in Gargano et al. (2002) and has been called the minimum branch vertices (MBV) problem by Cerulli et al. (2009). The heuristic starts with a random spanning tree and iteratively reduces the number of...

Weak b → c transitions are described by QCD currents c̄Γb with Γ = γ and γ5γ . If we are only interested in their matrix elements for pb = mbv + k, pc = mcv ′ + k, where the residual momenta k, k are small as compared to the heavy-quark masses mc,b, then we may expand these QCD currents in HQET operators of the form c̄v′ · · · bv with the appropriate quantum numbers divided by powers of mc,b. The...

Resveratrol, a polyphenol found in many plants, has antioxidant and anti-inflammatory actions. It also improves endothelial function and may be cardioprotective. Tumor necrosis factor-α (TNFα) causes oxidative stress and microvascular endothelial dysfunction. Whether resveratrol affects microvascular function in vivo and, if so, whether inflammatory cytokines antagonize its microvascular action...