We optimized the modulation of drug resistance by the irreversible augmentation of cytotoxicity of coincubating vinblastine (VNB) with VP16 and the reversible increase in cytotoxicity of coincubation of verapamil (VPL) with VNB and VP-16. VPL was administered as a loading dose (i.v.) (0.15 mg/kg) and then administered as a constant infusion (0.005 mg/kg) over 6 days. 24 h after verapamil, VNB 2...

åÌÓ„Ë ÚÎË (Hemiptera: Aphididae), Í‡Í Ë ÔÓ ̃Ë ̇ÒÂÍÓÏ ̊ ÓÚfl‰‡ Homoptera, ÔËÚ‡ ̨ÚÒfl ÙÎÓ ̋ÏÌ ̊Ï ÒÓÍÓÏ ‡ÒÚÂÌËÈ [2]. Ç Ò‚flÁË Ò ÚÂÏ, ̃ ÚÓ ̋ ÚÓÚ ÒÓÍ ÒÓ‰ÂÊËÚ ÎË ̄ ̧ 20% ÌÂÁ‡ÏÂÌËÏ ̊ı ‡ÏËÌÓÍËÒÎÓÚ, ÌÂÓ·ıÓ‰ËÏ ̊ı ‰Îfl ÌÓχΠ̧ÌÓ„Ó ‡Á‚ËÚËfl Ë ÊËÁ̉ÂflÚÂÎ ̧ÌÓÒÚË ÚÎÂÈ [3], ÔÓÒΉÌË “‚ ̊ÌÛʉÂÌ ̊ ‚ÒÚÛÔ‡Ú ̧” ‚ ÒËÏ·ËÓÚË ̃ÂÒÍË ÓÚÌÓ ̄ÂÌËfl Ò ̋̉ӈËÚÓ·ËÓÚË ̃ÂÒÍËÏË ·‡ÍÚÂËflÏË Ó‰‡ Buchnera, ÍÓÚÓ ̊ ‚ÓÒÔÓÎÌfl ̨Ú Ì‰ÓÒÚ‡ ̨ ̆ËÂ...

The activity of dihydropyrimidine dehydrogenase (DPD) in peripheral blood mononudear cells and plasma concentration of 5-fluorouracil (FUra) were simultaneously determined in cancer patients receiving FUra by protracted continuous infusion (300 mg/m!/day). Blood samples were drawn every 3 h over 24-h period and the resulting DPD and FUra values analyzed for circadian periodicity. In the seven p...

Spin-dependent scattering is considered to be the origin of giant magnetoresistance in magnetic multilayers, although the role of bulk or interface defects is still under discussion. We present calculations of spin-dependent impurity scattering potentials as a function of the impurity position in a Co/Cu-multilayer. The calculations are performed within spin density functional theory using a Gr...