Nitrogen used for pressurization of a fire extinguisher could be partially dissolved in the extinguishing agent, forming binary mixture accompanied by phase change while flowing inside pipeline. Notwithstanding widespread use system, few effective methods have been considered to predict two-phase flow performance nitrogen + extinguishant This paper presents study on steady-state pipeline, inclu...

Stochastic but roughly periodic LCRs (Local subsarcolemmal ryanodine receptor–mediated Ca Releases) during the late phase of diastolic depolarization (DD) in rabbit sinoatrial nodal pacemaker cells (SANCs) generate an inward current (INCX) via the Na /Ca exchanger. Although LCR characteristics have been correlated with spontaneous beating, the specific link between LCR characteristics and SANC ...

BACKGROUND The Purkinje fiber system has recently been implicated as an important driver of the rapid activation rate during long duration ventricular fibrillation (VF>2 minutes). The goal of this study is to determine whether this activity propagates to or occurs in the proximal specialized conduction system during VF as well. METHODS AND RESULTS An 8×8 array with 300 µm spaced electrodes wa...

The robust glycolytic metabolism of glioblastoma multiforme (GBM) has proven them susceptible to increases in oxidative metabolism induced by the pyruvate mimetic dichloroacetate (DCA). Recent reports demonstrate that the anti-diabetic drug metformin enhances the damaging oxidative stress associated with DCA treatment in cancer cells. We sought to elucidate the role of metformin's reported acti...

Alternative measures of muscle size, strength, and power to those used in previous studies could help resolve the controversy surrounding associations between polymorphisms of the angiotensin-I converting enzyme (ACE) and α-actinin-3 (ACTN3) genes and skeletal muscle phenotypes, and the responses to resistance training (RT). To this end, we measured quadriceps femoris muscle volume (Vm), physio...