BACKGROUND To study the short-term biological effect of anastrozole on serum estrogens, androgens, 17-hydroxyprogesterone (17OH-PGR), gonadotrophins, sex hormone binding globulin (SHBG) and bone metabolism markers. MATERIALS AND METHODS Thirty-four consecutive patients with advanced breast cancer received anastrozole 1 mg/day. Blood samples were taken before commencement of treatment and at 2...

OBJECTIVE Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone-sulfate (DHEA-S) are the most abundant steroid hormones in the body. Recently, DHEA-S has gained interest as an antidepressant substance, with positive effects on autoimmune disease such as lupus and ulcerative colitis, as well as obesity, cancer, cardiovascular disease and diabetes. Its effect on insulin resistance is also assu...

Dehydroepiandrosterone sulfotransferase (DHEA-ST), a steroid sulfotransferase (ST), has recently been purified from human liver cytosol and partially characterized. DHEA-ST has a subunit molecular mass of 35 kDa and is responsible for the majority of the sulfation of steroids and bile acids in the liver. For these studies, polyclonal antibodies to human liver DHEA-ST were raised in rabbits. The...

INTRODUCTION Rapid and accurate risk stratification in patients with community-acquired pneumonia (CAP) is an unmet clinical need. Cortisol to dehydroepiandrosterone (DHEA) ratio was put forward as a prognostic marker in sepsis. We herein validated the prognostic value of the adrenal hormones DHEA, DHEA-Sulfate (DHEAS), cortisol/DHEA-, cortisol/DHEAS- and DHEA/DHEAS-ratios in patients with CAP....

Dehydroepiandrosterone (DHEA) is a sex steroid precursor secreted by the adrenals in humans and other primates. It converts intracellularly to bioactive androgens and estrogens [20]. DHEA and its sulfate metabolite (DHEAS) production decreases with advancing age [21]. DHEA and DHEAS play an important role in regulating body fat and the immune system. They also influence the circulation of lipop...

The endogenous concentrations and the subcellular distribu tion of dehydroepiandrosterone (DHEA) and 5-androstene3/3,170-diol (ADIOL) were measured in malignant and nonmalignant human breast tissue from both preand postmenopausal women. DHEA 3-sulfate was measured only in the cytosol. A greater tissue-plasma gradient of DHEA was present with large variations. The highest concentration of DHEA a...

The endogenous concentrations and the subcellular distribution of dehydroepiandrosterone (DHEA) and 5-androstene-3 beta,17 beta-diol (ADIOL) were measured in malignant and nonmalignant human breast tissue from both pre- and postmenopausal women. DHEA 3-sulfate was measured only in the cytosol. A greater tissue-plasma gradient of DHEA was present with large variations. The highest concentration ...