MAS is a G protein-coupled receptor (GPCR) implicated in multiple physiological processes. Several physiological peptide ligands such as angiotensin-(1-7), angiotensin fragments and neuropeptide FF (NPFF) are reported to act on MAS. Studies of conventional G protein signaling and receptor desensitization upon stimulation of MAS with the peptide ligands are limited so far. Therefore, we systemat...

Background MAS is a life-threatening complication seen predominantly in children with SoJIA, often difficult to recognize because specific diagnostic criteria for MAS have not yet been devised. MAS is characterized by an overwhelming inflammatory reaction driven by excessive T cell expansion and hemophagocytic macrophages. Preliminary studies suggest that high sIL-2R α serum levels and sCD163 m...

Koi herpesvirus (KHV) and carp edema virus (CEV) are potential risks for the koi trade global common aquaculture. Due to severe impact of both viruses, a robust diagnostic tool was required, capable detecting distinguishing infections with high accuracy precision. The aim this study describe real-time duplex TaqMan PCR assay simultaneous detection KHV CEV in koi. Two pairs primers two probes we...

We present diffraction-limited (30 mas) bispectrum speckle interferometry observations of the Mira star R Cas with the Russian 6 m SAO telescope. The speckle interferograms were recorded through narrow-band interference filters with centre wavelength/bandwidth of 671 nm/6 nm and 714 nm/6 nm (strong TiO absorption band), 700 nm/6 nm (moderate TiO absorption), and 1045 nm/9 nm (continuum). The re...

Arsenite [As(III)] and methylarsenite [MAs(III)] are the most toxic inorganic and methylated arsenicals, respectively. As(III) and MAs(III) can be interconverted in the unicellular cyanobacterium Nostoc sp. PCC 7120 (Nostoc), which has both the arsM gene (NsarsM), which is responsible for arsenic methylation, and the arsI gene (NsarsI), which is responsible for MAs(III) demethylation. It is not...

The aim of the study was to evaluate splenic glucose metabolism in macrophage activation syndrome (MAS), characterized by overwhelming systemic inflammation. Splenic F-fluorodeoxyglucose (FDG) uptake was compared in patients with MAS and sepsis using positron emission tomography/computed tomography (PET/CT).Clinical and FDG-PET/CT findings from patients with MAS and those with culture-proven se...

OBJECTIVE The aim of this study was to examine the epidemiological and reporting characteristics as well as the methodological quality of meta-analyses (MAs) of observational studies published in Chinese journals. METHODS 5 Chinese databases were searched for MAs of observational studies published from January 1978 to May 2014. Data were extracted into Excel spreadsheets, and Meta-analysis of...

STUDY OBJECTIVES To compare the efficacy of a mandibular advancement splint (MAS) and a novel tongue stabilizing device (TSD) in the treatment of obstructive sleep apnea (OSA). DESIGN A randomized crossover design was used. PATIENTS Twenty-seven patients (20 male, 7 female), recruited from a tertiary hospital sleep clinic. MEASUREMENTS AND RESULTS The apnea-hypopnea index (AHI) was reduce...

In software engineering community there is an increasing effort of design and development of multiagent systems (MAS). Among several issues emerging from this initiative, complexity, quality and uncertainty issues have not yet received much attention. The main factors affecting quality of MAS are complexity and knowledgeability. Complexity of MAS can be defined in terms of structural and algori...

Masev (MAs Software engineering EValuation framework) is an online application that allows analyzing and comparing methods, techniques and environments for developing MAS. Moreover, Masev allows the evaluation of how these methods and tools support the development of Organizational MAS and Service-oriented MAS. Finally, Masev provides a quantitative comparison based on a simple metric whose par...