This research was aimed to optimize the extraction conditions of three phenolic compounds: total phenolics, flavonoids and condensed tannins, from White Horehound’s leaves (Marrubium vulgare L.). Distilled water and different organic solvents such as: methanol, ethanol and acetone, were used, with various concentrations (20% 80%, v/v), temperatures (20 ̊C 60 ̊C) and extraction times (30 450 min)....

Marrubium vulgare and Withania somnifera are used in folk medicine of several countries. Many researches showed that they are used for the treatment of variety of diseases due to their antioxidant effects. The present aim of this study was to evaluate the antihepatotoxic and antioxidant activities of the both extracts against carbon tetrachloride (CCl4)-induced hepatic damage in rats. Both extr...

PURPOSE In the present study we aimed to quantify marrubiin, as the major active compound, in the aerial parts of Marrubium vulgare from Iran using a HPTLC-densitometry technique. METHODS Quantitative determination of marrubiin in M. vulgare methanol extract was performed by HPTLC analysis via a fully automated TLC scanner. Later on, the in vitro antioxidant activity of the M. vulgare methano...

Objective: In the present study, we examined the antioxidant effect of Marrubium vulgare L. infusion (MVI) on renal and liver function in alloxan diabetic rats. Materiel and methods: Animals were divided into 4 groups: the control, treated rats with MVI (MVI), diabetic (Diab) and diabetic treated rats with MVI (Diab + MVI), for 30 days. Thereafter, blood samples were collected for the dosage of...

(Isca Silurum), the base of the Second Augustan Legion (legio II Augusta), was discovered an amphora, which had contained Aminean wine, a high quality Italian white wine that kept well.27 Celsus prescribes two uses for this wine. Firstly, as a cure for diarrhoea one should eat half a pound of bread soaked in neat Aminean wine, then something roasted (particularly poultry), then drink the Aminea...

Nutlets of 20 taxa of the tribe Marrubieae were examined by scanning electron microscopy (SEM) and detailed descriptions of nutlet micromorphological features for all examined taxa are provided. The nutlets exhibited variation in size, shape, color and surface sculpturing. The nutlets shape of most species studied is ovate, but rounded, broad ovate, elliptic, lanceolate, triangular and oblong c...

Isoproterenol injection (100 mg/kg; sc) produced changes in ECG pattern including ST-segment elevation and suppressed R-amplitude. The methanolic extract of M. vulgare at doses of 10, 20, and 40 mg/kg significantly amended the ECG changes. A severe myocardial necrosis and edematous along with a sharp reduction in the arterial blood pressure, left ventricular contractility (LVdP/dt(max or min)),...