نتایج جستجو برای: manganese pyrophosphate

تعداد نتایج: 30293  

Journal: :Journal of bacteriology 2005
Han-Yu Sun Tzu-Ping Ko Chih-Jung Kuo Rey-Ting Guo Chia-Cheng Chou Po-Huang Liang Andrew H-J Wang

Hexaprenyl pyrophosphate synthase (HexPPs) from Sulfolobus solfataricus catalyzes the synthesis of trans-C(30)-hexaprenyl pyrophosphate (HexPP) by reacting two isopentenyl pyrophosphate molecules with one geranylgeranyl pyrophosphate. The crystal structure of the homodimeric C(30)-HexPPs resembles those of other trans-prenyltransferases, including farnesyl pyrophosphate synthase (FPPs) and octa...

Journal: :The American journal of clinical nutrition 2015
Judy L Aschner Adam Anderson James Christopher Slaughter Michael Aschner Steven Steele Amy Beller Amanda Mouvery Heather M Furlong Nathalie L Maitre

BACKGROUND Manganese, an essential metal for normal growth and development, is neurotoxic on excessive exposure. Standard trace element-supplemented neonatal parenteral nutrition (PN) has a high manganese content and bypasses normal gastrointestinal absorptive control mechanisms, which places infants at risk of manganese neurotoxicity. Magnetic resonance (MR) relaxometry demonstrating short T1 ...

Journal: :Critical reviews in toxicology 2005
Michael Aschner Keith M Erikson David C Dorman

Manganese (Mn) is an essential mineral that is found at low levels in food, water, and the air. Under certain high-dose exposure conditions, elevations in tissue manganese levels can occur. Excessive manganese accumulation can result in adverse neurological, reproductive, and respiratory effects in both laboratory animals and humans. In humans, manganese-induced neurotoxicity (manganism) is the...

Journal: :The Boston Medical and Surgical Journal 1862

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2006
David C Dorman Melanie F Struve Brian A Wong Janice A Dye Ian D Robertson

High-dose manganese exposure is associated with parkinsonism. Because manganese is paramagnetic, its relative distribution within the brain can be examined using magnetic resonance imaging (MRI). Herein, we present the first comprehensive study to use MRI, pallidal index (PI), and T(1) relaxation rate (R1) in concert with chemical analysis to establish a direct association between MRI changes a...

2011
Birgit Claus Henn Jonghan Kim Marianne Wessling-Resnick Martha María Téllez-Rojo Innocent Jayawardene Adrienne S Ettinger Mauricio Hernández-Avila Joel Schwartz David C Christiani Howard Hu Robert O Wright

BACKGROUND Given mounting evidence for adverse effects from excess manganese exposure, it is critical to understand host factors, such as genetics, that affect manganese metabolism. METHODS Archived blood samples, collected from 332 Mexican women at delivery, were analyzed for manganese. We evaluated associations of manganese with functional variants in three candidate iron metabolism genes: ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Kathryn L Kavanagh Kunde Guo James E Dunford Xiaoqiu Wu Stefan Knapp Frank H Ebetino Michael J Rogers R Graham G Russell Udo Oppermann

Osteoporosis and low bone mass are currently estimated to be a major public health risk affecting >50% of the female population over the age of 50. Because of their bone-selective pharmacokinetics, nitrogen-containing bisphosphonates (N-BPs), currently used as clinical inhibitors of bone-resorption diseases, target osteoclast farnesyl pyrophosphate synthase (FPPS) and inhibit protein prenylatio...

Journal: :The Journal of biological chemistry 2006
Jing-Yuan Liu David E Timm Thomas D Hurley

Thiamine pyrophosphokinase transfers a pyrophosphate group from a nucleoside triphosphate, such as ATP, to the hydroxyl group of thiamine to produce thiamine pyrophosphate. Deficiencies in thiamine can result in the development of the neurological disorder Wernicke-Korsakoff Syndrome as well as the potentially fatal cardiovascular disease wet beriberi. Pyrithiamine is an inhibitor of thiamine m...

2014
Koba A. Lomashvili Sonoko Narisawa Jose Luis Millán W. Charles O’Neill

Plasma levels of pyrophosphate, an endogenous inhibitor of vascular calcification, are reduced in end-stage renal disease and correlate inversely with arterial calcification. However, it is not known whether the low plasma levels are directly pathogenic or are merely a marker of reduced tissue levels. This was tested in an animal model in which aortas were transplanted between normal mice and E...

Journal: :CrystEngComm 2022

Multiscale and multitool advanced characterisation of pyrophosphate-stabilised amorphous calcium carbonates allowed building a cluster-based model paving the way for tunable biomaterials.

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید