results there were 39 cases with lymph node metastasis in 59 malignant tumors, and 0 cases in 6 benign follicular type tumors. the staining scores by jt-95 of the 39 tumors with lymph node metastasis were 5+ in eight cases and 6+ in 31 cases. on the other hand, the scores of 20 malignant tumors without lymph node metastasis were < 4+ in all of the cases. in the co-cultured assay, numerous adhes...

Intranodal palisaded myofibroblastoma (IPM) is a kind of mesenchymal tumor with benign behaviour. The origin this differentiated smooth muscle cells and myofibroblasts. This rare entity differential diagnosis from malignant tumors important for clinicians pathologists. etiology has not been explained adequately. Age range between 2nd 8th decades the life it seen more frequently in males. Inguin...

purpose: to evaluate of proton therapy (pt) for neurosurgery patients and is also to explain the need for this system in iran. methods: a literature review was conducted (1984–2016). the strategy included a combination of keywords including proton therapy, neck, neurosurgery, brain, head, tumor, spine, arteriovenous malformation (avms), cervical and spine in database of pubmed. new generation p...

AIM To investigate the significance of c-kit gene mutation in gastrointestinal stromal tumors (GIST). METHODS Fifty two cases of GIST and 28 cases of other tumors were examined. DNA samples were extracted from paraffin sections and fresh blocks. Exons 11, 9 and 13 of the c-kit gene were amplified by PCR and sequenced. RESULTS Mutations of exon 11 were found in 14 of 25 malignant GISTs (56%)...

Uterine perivascular epithelioid cell tumors (PEComas) are rare mesenchymal tumors. Many have malignant behavior, and no successful treatment strategy has been established. Identification of mutations in the tuberous sclerosis 1 (TSC1) and TSC2 genes producing constitutive activation of the mammalian target of rapamycin (mTOR) pathway presents an opportunity for targeted therapy. Patients with ...

Although many cancers are maintained by tumor-initiating cells, this has not been shown for mesenchymal tumors, in part due to the lack of unique surface markers that identify mesenchymal progenitors. An alternative technique to isolate stem-like cells is to isolate side population (SP) cells based on efflux of Hoechst 33342 dye. We examined 29 mesenchymal tumors ranging from benign to high-gra...

From March 1980 to March 1989 a total number of 2254 (7.6%) new malignant cases from Kerman province were diagnosed by examination of surgical specimens, blood films and bone marrow smears. The crude relative frequency of cancers was studied and compared with other areas of Iran. Gastric (11.36%) and urinary bladder (7.01 %) carcinomas were significantly more common in Kerman province than...

Hepatic angiosarcoma is a mesenchymal tumor originating from liver sinusoidal endothelial cells. It is an extremely rare malignant neoplasm accounting for less than 1% of primary malignant liver tumors. The deregulated coagulopathy that can be seen in hepatic angiosarcoma fulfills the clinical diagnostic criteria of disseminated intravascular coagulation. However, the mechanism that governs thi...

Extraskeletal osteosarcomas are rare malignant mesenchymal tumors. They mimic many bone and cartilage forming soft tissue tumors and tumor like conditions. Most cases pursue an aggressive clinical course with high rate of local recurrence and metastasis. We report a case of extraskeletal osteosarcoma of the left gluteal region in a 50 year old male with varied histology. It was diagnosed as mal...

lipoma is a benign mesenchymal tumor of fat with uncertain pathogenesis. although the most common mesenchymal neoplasm in trunk and proximal portions of the extremities, it is rarely seen in the oral cavity. oral lipomas are clinically soft, smooth-surfaced nodular masses that mostly are less than 3 cm in size. typically the tumor is asymptomatic unless bitten or become noticeable because of th...