A prospective immunological study of patients with proptosis due to intraorbital lesions composed largely or exclusively of lymphoid tissue indicates that the use of antisera to specific heavy and light chain antibody components can be helpful in distinguishing between polyclonal and truly neoplastic monoclonal disorders. On the basis of combined histological and immunological information it is...

CD45 is a protein tyrosine phosphatase, which is well-known for regulating antigen receptor signalling in T and B cells via its effect on Src kinases. It has recently been shown that CD45 can also dephosphorylate Janus kinases (Jaks) and thereby regulate Signal transducer and activator of transcription (Stat) activation and cytokine-induced proliferation in lymphocytes. Consequently, CD45 dysre...

We have used recombinant human erythropoietin (rHuEPO) in a phase I/II clinical trial to evaluate its ability to reverse refractory anemia in hematologic disorders. rHuEPO was administered subcutaneously 5 days per week at escalating doses (50 to 150 U/kg per day). The aim of treatment was a hemoglobin (Hb) level greater than or equal to 10 g/dL without blood transfusion. Of 25 patients treated...

By Henrik Griesser, Douglas Tkachuk, Marciano D. Reis, and Tak W. Mak L YMPHOID LEUKEMIAS and malignant lymphomas are neoplasms characterized by the proliferation of cells derived from the lymphoid tissue and its precursors. Like other malignant hematological disorders, the majority of these lymphoid malignancies are of monoclonal origin.’ Although clonality does not necessarily correlate with ...

Summary Since 2000, new drugs for treating lymphoproliferative diseases have been introduced in haematology, and their initial indications gradually expanded. Some of the so-called „target molecules“ shown good efficacy when some malignant non-Hodgkin lymphomas. The possibility achieving therapeutic disease control indolent lymphomas using with a different mechanism action from that cytostatics...

Cutaneous T cell lymphomas (CTCLs) are a heterogenous group of lymphoproliferative disorders caused by clonally derived, skin-invasive T cells. Mycosis fungoides (MF) and Sezary syndrome (SS) are the most common types of CTCLs and are characterized by malignant CD4(+)/CLA(+)/CCR4(+) T cells that also lack the usual T cell surface markers CD7 and/or CD26. As MF/SS advances, the clonal dominance ...

Waldenstrom's macroglobulinamia (WM) is a rare malignant lymphoproliferative disorder, characterized by monoclonal IgM paraproteinemia and neoplastic proliferation of malignant lymphoplasmacytoid cells in the bone marrow. Traditionally, WM has been treated with modalities similar to those used in the management of other indolent lymphomas. Just recently, based on impressive clinical trial resul...

A simple reproducible in vitro B-cell colony assay system was used to evaluate B-cell growth in controls and patients with chronic lymphocytic leukemia (CLL). All six CLL patients studied formed B-cell colonies. The number of colonies was significantly less in patients than controls (66 +/- 18 versus 127 +/- 8). CLL colonies were shown to be monoclonal and appeared to reflect the circulating ma...

Crohn's disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract. Patients with this disease have an increased risk for both intestinal and various extra-intestinal malignancies. This risk is mainly attributed to chronic inflammation and druginduced immunosuppression. Various extra-intestinal malignancies, such as lymphoproliferative disorders and non-melanoma skin cancers ...