Introduction The benefits of antihypertensive therapy in reducing the mortality from certain complications of hypertension are now well established. Improved prognosis in respect of the malignant phase was demonstrated by Morrison (1953) and quickly confirmed by Rosenheim (1954), Schroeder (1954) and McMichael & Murphy (1955). Simultaneously, Smirk (1953) showed an improved prognosis in respect...

We measured plasma concentrations of immunoreactive endothelin-1 (irET-1) in the prehypertensive and hypertensive phases in spontaneously hypertensive rats (SHR) and in malignant hypertension caused by deoxycorticosterone acetate (DOCA)-salt administration in SHR. We also measured concentrations of this peptide in another model of malignant hypertension, the two-kidney, one clip (2K1C) renovasc...