Several factors contribute to organ dysfunction in septic shock patients, and once the inflammatory response has been activated, many organ systems can be adversely affected. A marked fall in systemic vascular resistance results from arterial and venous dilatation. This is accompanied by leakage of plasma into the extravascular space, leading to relative hypovolemia. The microcirculation is adv...

In this study, the effects of maldistribution coefficient on thermo-hydraulic performance discontinuous fin printed circuit heat exchanger (DF-PCHE) entrance head and channels are numerically investigated. To improve flow uniformity at head, in with three types spoiler perforated boards (SPBs) having 3 × 3, 4 4, 5 holes kinds hole diameters (Φd = 30, 25, 20 mm), respectively, compared to an no ...

The traditional role of iron chelation therapy has been to reduce body iron burden via chelation of excess metal from organs and fluids and its excretion via biliary-fecal and/or urinary routes. In their present use for hemosiderosis, chelation regimens might not be suitable for treating disorders of iron maldistribution, as those are characterized by toxic islands of siderosis appearing in a b...

Present parametric study shows that the flowrate, number of channels, hydrodynamic resistances and phase ratio significantly affect maldistribution in parallel microfluidic reactors (i.e., numbering-up). Especially effect flow rate has not been reported before. However, these findings are a qualitative nature due to high degree variability between experiments. Additional experiments show stable...

To understand the influence of collector design parameters on the flow distribution among the solar collector absorber tubes, and as a first step to any detailed analysis of the influence of flow on heat transfer in the collector and on its consequent thermal performance, this study investigates the distribution of flow through a typical system consisting of two manifolds connected by a number ...