Objective: Psoriasiform drug eruptions can be induced by several drugs. Psoriasis is a chronic inflammatory disease characterized T-cell-mediated cytokine production that drives the hyperproliferation and abnormal differentiation of keratinocytes. Drugs cause new lesions when there no prior history or family psoriasis. Based on psoriatic eruption probability score, β‐blockers, synthetic anti‐ma...

The continuous culture of Plasmodium falciparum is often seen as a means to an end, that end being to probe the biology of the parasite in question, and ultimately for many in the malaria drug discovery arena, to identify means of killing the parasite in order to treat malaria. In vitro continuous culture of Plasmodium falciparum is a fundamental requirement when undertaking malaria research wh...

Malaria is an infectious disease caused by the genus Plasmodium such as Plasmodium falciparum (P. falciparum), Plasmodium ovale, Plasmodium vivax and Plasmodium malariae. Among them, P. falciparum is the parasite responsible for most severe diseases and fatal cases, which may kill over one millions of people per annum. The parasite, P. falciparum is genetically diverse and has multiple independ...

Pyrimethamine is an antimalarial drug which possesses schizonticidal activity in both tissue and blood phases. Though pyrimethamine is known to inhibit folic acid metabolism of malarial parasites by binding with folio acid reductase (6), the cytological effect on the parasites is not completely understood. To our knowledge, there has been no study until now on the morphological effects of pyrim...

background: electrolytes play an important role in the normal functioning of human body. electrolyte imbalance and mineral disturbances is the common clinical manifestation in several infectious diseases including malaria. malaria is a mosquito borne serious infectious disease of the world. plasmodium vivax and p. falciparum are the main agents responsible for malaria in pakistan. electrolyte i...

The Plasmodium falciparum translationally controlled tumor protein (TCTP) is a homolog of the mammalian histamine-releasing factor (HRF), which causes histamine release from human basophils and IL-8 secretion from eosinophils. Histamine, IL-8, and eosinophils have been reported to be elevated in patients with malaria. This study was undertaken to determine whether malarial TCTP is found in the ...

Chronic immunological complications of malaria include hyperreactive malarial splenomegaly (HMS) and quartan malarial nephropathy. HMS represents an abnormal immunological response to recurrent malarial infections as a result of defective T suppressor cell regulation. On the other hand, quartan malarial nephropathy, which usually presents in childhood with nephrotic syndrome, is not responsive ...