The large number of protein kinases makes it impractical to determine their specificities and substrates experimentally. Using the available crystal structures, molecular modeling, and sequence analyses of kinases and substrates, we developed a set of rules governing the binding of a heptapeptide substrate motif (surrounding the phosphorylation site) to the kinase and implemented these rules in...

with the rise of importance of sport as a social phenomenon in recent decades, more public attention has been paid to the issue of the legal nature of the rules governing social relations in sports. the issue raised above are only a part of a much broader topic that involves questions of relations of a classical westphalian state and changes in the international community as well as issues of t...

in the case of abuse of right  of  freedom of trade, intentional fault or negligence, resort  to unlawful means and act contrary to professional ethics and in general, fulfillment of conditions of compensation of loss according to governing rules in legal systems, commercial rivals have tortious liability within the framework of traditional principles of tort law. nowadays, day by day, cases of...

The attribution rules are the first technical means by which law applicable to disputes with a foreign element is Since rule raised in international determined, Including electronic information supply contract disputes, service contract, often associated more than one Where I concluded through Internet legal system, Among controls between two parties of different nationalities, that judge relie...

normative constitution is the highest law system and the consistency of this system requires, following the rules below from the superior rules. from this view, preservation of the constitution as the fundamental law governing the legal system of each country needs to legal ways of controlling instruments. this process is followed from two distinct complementary routes of constitutionalization ...