نتایج جستجو برای: major axis

تعداد نتایج: 714053  

Journal: :American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2012
Yoshinobu Ishitobi Shinya Nakayama Kana Yamaguchi Masayuki Kanehisa Haruka Higuma Yoshihiro Maruyama Taiga Ninomiya Shizuko Okamoto Yoshihiro Tanaka Jusen Tsuru Hiroaki Hanada Koichi Isogawa Jotaro Akiyoshi

Major depressive disorder (MDD) and panic disorder (PD) are common and disabling medical disorders with stress and genetic components. Dysregulation of the stress response of the hypothalamic-pituitary-adrenal axis, including the corticotrophin-releasing hormone (CRH) signaling via primary receptors (CRHR1 and CRHR2), is considered to play a major role for onset and recurrence in MDD and PD. To...

Journal: :Psychoneuroendocrinology 2014
Florian Hardeveld Jan Spijker Sophie A Vreeburg Ron De Graaf Sanne M Hendriks Carmilla M M Licht Willem A Nolen Brenda W J H Penninx Aartjan T F Beekman

INTRODUCTION Although HPA-axis activity has been studied extensively in relation to depression, there is no consensus whether HPA-axis parameters predicts major depressive disorder (MDD) recurrence. We investigated whether HPA-axis parameters (cortisol awakening response (CAR), the dexamethasone suppression test (DST) and evening cortisol) predict time to recurrence in remitted subjects with a ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2010
David M Lyons Paul S Buckmaster Alex G Lee Christine Wu Rupshi Mitra Lauren M Duffey Christine L Buckmaster Song Her Paresh D Patel Alan F Schatzberg

Coping with intermittent social stress is an essential aspect of living in complex social environments. Coping tends to counteract the deleterious effects of stress and is thought to induce neuroadaptations in corticolimbic brain systems. Here we test this hypothesis in adult squirrel monkey males exposed to intermittent social separations and new pair formations. These manipulations simulate c...

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