BACKGROUND The Manchester triage system (MTS) is now widely used in UK accident and emergency (A&E) departments. No clinical outcome studies have yet been published to validate the system. Safety of triage systems is related to the ability to detect the critically ill, which has to be balanced with resource implications of overtriage. OBJECTIVES To determine whether the MTS can reliably detec...

BACKGROUND: The control of proliferation, differentiation and survival of normal and malignant cells in the tumour microenvironment is under the control of a wide range of different factors, including cell:cell interactions, cytokines, growth factors and hormonal influences. However, the ways in which these factors interact are poorly understood. In order to compare the effects of multiple vari...

This report discusses the cross-section shapes and growth curves created by different proliferation algorithms in an in silico model of in vitro multicellular tumor spheroid growth (MTS). The in vitro MTS system is a model of in vivo tumor growth. The in silico model described herein represents aspects of MTS growth, including its layered structure and growth patterns. An exploration of four al...

10.1083/jcb.1726rr1jcb.1726rr1Kendall [email protected] on MTs D ynactin can skate along the length of a microtubule (MT), giving a boost to the attached dynein motor’s forward progress, according to Tara Culver-Hanlon, Stephen King (University of Missouri, Kansas City, MO), and colleagues. Dynein is a poorly processive motor compared with ...

The ever-increasing complexity of software systems makes them hard to comprehend, predict and tune due to emergent properties and non-deterministic behaviour. Complexity arises from the size of software systems and the wide variety of possible operating environments: the increasing choice of platforms and communication policies leads to ever more complex performance characteristics. In addition...

In our previous work we have shown that Mahalanobis kernels are useful for support vector classifiers both from generalization ability and model selection speed. In this paper we propose using Mahalanobis kernels for function approximation. We determine the covariance matrix for the Mahalanobis kernel using all the training data. Model selection is done by line search. Namely, first the margin ...

Suspensions of multicellular mammary tumor spheroids (MTS) were allowed to interact with confluent monolayers of endothelial cells cultured on top of collagen gels. A number of early and late interactions between MTS and endothelial cell monolayers occurred. The early phase was characterized by the attachment of MTS to the culture and retraction of endothelial cells near the attached spheroid. ...

The Mahalanobis distance is commonly used in multi-object trackers for measurement-to-track association. Starting with the original definition of the Mahalanobis distance we review its use in association. Given that there is no principle in multi-object tracking that sets the Mahalanobis distance apart as a distinguished statistical distance we revisit the global association hypotheses of multi...

Objective in this paper, we have done Mahalanobis Discriminant analysis to EEG data of experiment objects which are recorded impersonally come up with a relatively accurate method used in feature extraction and classification decisions. Methods In accordance with the strength of  wave, the head electrodes are divided into four species. In use of part of 21 electrodes EEG data of 63 people, we ...

in this study, a two-objective mixed-integer linear programming model (milp) for multi-product re-entrant flow shop scheduling problem has been designed. as a result, two objectives are considered. one of them is maximization of the production rate and the other is the minimization of processing time. the system has m stations and can process several products in a moment. the re-entrant flow sho...