background : magnesium is the second most abundant intracellular cation. it plays an important role in insulin homeostasis and glucose metabolism through multiple enzymatic reactions. with increasing data on magnesium deficiency in diabetic patients and epidemiological studies demonstrating magnesium deficiency as a risk factor for diabetes, it is logical to search for its possible beneficial e...

BACKGROUND Rest cramps (also known as nocturnal leg cramps) are very common in a geriatric population. Oral magnesium supplements are marketed for prophylaxis of such cramps but clinical trials exploring the efficacy of oral magnesium conflict. A therapeutic trial of intravenous magnesium overcomes the limited oral bioavailability of magnesium and better assesses its therapeutic potential. ME...

When extracellular magnesium is reduced by a factor of 50 (from 1.0 to 0.02 mM), the total intracellular magnesium of a spontaneously transformed clone of 3T3 cells decreases by 30-50%. Protein synthesis rates in these cells were measured as the intracellular magnesium decreased. Protein synthesis rates and magnesium content were found to decrease in parallel with each other. At 3 hr, a decreas...

Determination of magnesium in mononuclear blood cells may provide useful information about intracellular magnesium. Mononuclear blood cell preparations are frequently contaminated with granulocytes. We determined the normal reference interval for magnesium content and concentration of granulocytes and compared it with magnesium in mononuclear blood cells. The mean granulocyte magnesium concentr...

Whereas in the general population magnesium deficits are most often thought to result mainly in calf cramps (which are generally not considered to be life threatening), it is less well known that a magnesium deficit induced by a magnesium-deficient diet in humans resulted in severe cardiac arrhythmias [5] . Other studies as, for example, an epidemiological study in Germany showed that low serum...

Whereas in the general population magnesium deficits are most often thought to result mainly in calf cramps (which are generally not considered to be life threatening), it is less well known that a magnesium deficit induced by a magnesium-deficient diet in humans resulted in severe cardiac arrhythmias [5] . Other studies as, for example, an epidemiological study in Germany showed that low serum...

1. Respiratory alkalosis accompanies the clinical syndrome of tetany, precipitates cardiac arrhythmias and predisposes to coronary vasoconstriction. Magnesium plays a critical role in the maintenance of membrane function, and magnesium depletion is often associated with cardiac arrhythmias or vasoconstriction. 2. As technology for detecting circulating ionized magnesium (the most interesting fo...

OBJECTIVE Magnesium deficiency has been associated with insulin resistance (IR) and increased risk for type 2 diabetes in adults. This study was designed to determine whether obese children exhibit serum or dietary magnesium deficiency and its potential association with IR. RESEARCH DESIGN AND METHODS We studied 24 obese nondiabetic children (BMI > or =85th percentile) and 24 sex- and puberty...

magnesium is extracted with a chloroform solution of n-p-tolyl-2- thenohydroxamic acid (pttha) from aqueous solution of ph 9.5 .mg-pttha complex is colourless and the colour is developed by adding quinalizarin into the extract. lmax and e of the complex are 590nm and 2.8´103 lmol -1cm-1respectively.most common  ions do not interfere in the determination of magnesium. the spectral characteristic...

BACKGROUND Because magnesium blocks the N-methyl-D-aspartate receptor and its associated ion channels, it can prevent central sensitization caused by peripheral nociceptive stimulation. However, transport of magnesium from blood to cerebrospinal fluid (CSF) across the blood-brain barrier is limited in normal humans. The current study was designed to evaluate whether perioperative intravenous ma...