Different porphyrin conformations are believed to play a role in controlling the cofactor properties in natural tetrapyrrole-protein complexes. In order to study the correlation between macrocycle nonplanarity and physicochemical properties in detail, a series of six porphyrins with graded degree of macrocycle distortion was investigated. These conformationally designed porphyrins are based on ...

This contribution describes the synthesis of a novel pyrazole-pyrrole building block and its use in the formation of a non-aromatic, Schiff base-type macrocycle incorporating a chromophore and H-bonding donor and acceptor functionalities inside and outside of the macrocycle, which makes it predestined for molecular recognition systems.

The molecular structure of a macrocycle with a 24-membered ring, a thiadiazole-containing expanded heteroazaporphyrinoid, has been, for the first time, directly characterised by a synchronous gas electron diffraction and mass spectrometric experiment and DFT calculations; the molecule has the equilibrium structure of C(3h) symmetry with a planar macrocycle.

A bisporphyrin macrocycle was constructed from a porphyrin-based diyne monomer in one step through alkyne metathesis. The fullerene binding studies (C(60), C(70) and C(84)) showed the highest binding affinity of the macrocycle for C(84), which is in great contrast to its bisporphyrin four-armed cage analogue that showed the strongest binding with C(70).

By using [RuCl2(p-Cymene)]2/Cs2CO3 as an efficient catalyst system, the readily available, inexpensive aryl methanols were firstly employed for dehydrogenative synthesis of aryl substituted 1,3,5-triazine derivatives. Due to the inherent stability of alcohols in contrast with aldehydes, our synthetic protocol is adaptable to a broad substrate scope, there is no need for stringent protection dur...

We report population-based rates of congenital anomalies in the Rivne province of Ukraine. The rates are significantly higher in the northern half of Rivne, a region called Polissia which is polluted by Chornobyl ionizing radiation. In this region of forested wet-lands, also called Prypiat Marshlands, the soils are distinct from those in non-Polissia. The soils in Polissia transfer caesium more...

A highly efficient one-pot approach for the synthesis of carbonyl 2-amino-pyrimidines from 1,3-diynes and guanidine in the presence of Cs2CO3 and DMSO has been described. In these reactions, 1,3-diynes act as a precursor of buta-1,2,3-trienes and guanidine serves as the N-C[double bond, length as m-dash]N source for the construction of pyrimidines. This methodology proves to be a tandem regiose...