We used the inositol 1,4,5-trisphosphate (IP3 ) biosensor, the pleckstrin homology (PH) domain of PLC 1 (phospholipase C) tagged with enhanced green fluorescent protein (eGFP-PHPLC ), to examine muscarinic acetylcholine (mACh) receptor regulation of phospholipase C/IP3 signaling in intact single hippocampal neurons in “real time.” Initial experiments produced a pharmacological profile consisten...

In this research, a gas turbine blade cascade was investigated. Flow analysis around the blade was conducted using RSM and RNG.K-ε turbulence modeling and it is simulated by Fluent software. The results were considered for the cases as Mach number loss at the trailing edge of blade caused by vortexes that were generated at the end of blade. Effect of cooling flow through the trailing edge on th...

A preconditioned five-equation two-phase model coupled with an interface sharpening technique is introduced for simulation of a wide range of multiphase flows with both high and low Mach regimes. Harten-Lax-van Leer-Contact (HLLC) Riemann solver is implemented for solving the discretized equations while tangent of hyperbola for interface capturing (THINC) interface sharpening method is applied ...

A probe consisting of two poloidally separated triple probes and a Mach probe ~TMT probe! has been designed and installed on the H-1 heliac to study fluctuations. Mach probes are shown to be sensitive to the fluctuations in the electron density, electron and ion temperatures, and ion drift velocity. If the ion Larmor radius is much larger than the characteristic probe dimension, then the Mach p...

Direct numerical simulations (DNS) are carried out to study the laminar stability properties of an effusioncooled adiabatic flat-plate boundary layer at Mach 6. Through four aligned rows of holes, cold gas is blown into the boundary layer at the wall and background disturbances are excited at the wall upstream of the holes. Two cases are compared, with small and large spanwise spacing of the ho...

A spatial domain optimal trade-off Maximum Average Correlation Height (OT-MACH) filter has been previously developed and shown to have advantages over frequency domain implementations in that it can be made locally adaptive to spatial variations in the input image background clutter and normalised for local intensity changes. In this paper we compare the performance of the spatial domain (SPOT-...

About a century ago, Ernst Mach argued that Archimedes’s deduction of the principle of the lever is invalid, since its premises contain the conclusion to be demonstrated. Subsequently, many scholars defended Archimedes, mostly on historical grounds, by raising objections to Mach’s reconstruction of Archimedes’s deduction. In the debate, the Italian philosopher and historian of science Giovanni ...

~ blade-element theory for aanid--ow compre8sor8has been deoeloped and applied to the anulysi8 of the. effects of basic deeign variabkwvuch as Mach number, blude loading, and mJocily didn”buiion on compree80r performance. A graphi.cul method tlwt ia u8efulfor approximate design cakulati0n8 i8 pre8ented. Tle relati0n8 among 8e8eralefinci48 useful in compressor design are derived and &cu8sed. The...

Shock waves generated at different parts of vehicle interact with the boundary layer over the surface at high Mach flows. The adverse pressure gradient across strong shock wave causes the flow to separate and peak loads are generated at separation and reattachment points. The size of separation bubble in the shock boundary layer interaction flows depends on various parameters. Reynolds-averaged...